Volume II, Issue 6: June 2021
American Federation for Medical Research (AFMR) Insights
AFMR Website Meetings/Events Calendar Submit a JIM manuscript Follow AFMR on Twitter
IN THIS ISSUE

 

Samrat U. Das, MD, AFMR President
Samrat U. Das, MD
AFMR President
In April, the AFMR National Council had a four-hour meeting to review the past year and focus on objectives for the future. There are two such meetings annually.

Top items covered included:

Membership
A major issue discussed was recruitment of new members and retention of present ones. New national and regional leadership took office on May 1, and this subject will be a major focus on both the national and local levels of the organization.

AFMR provides great value for its members, including the following and more:

AFMR members who are not current on their dues will lose access to their journal subscriptions and other benefits.

Please check to see if your dues are current. Payment can be made securely online. Also, please promote AFMR to colleagues. A full list of benefits is included in the AFMR membership flyer.

More from AFMR President Samrat U. Das

 

The AFMR Virtual Education Series spring season continues in June with two new offerings.

All are free to AFMR members, as well as to non-members. Feel free to share the information with colleagues. Registration is required.

Tuesday, June 8, 2021
2:00 pm-3:30 pm Eastern/11:00 am-12:30 pm Pacific
BUILDING A PEER MENTORSHIP PROGRAM

Kristen Nadeau Kristen Nadeau
University of Colorado Denver - Anschutz Medical Campus
Jane Reusch Jane Reusch
University of Colorado Denver - Anschutz Medical Campus

 
Tuesday, June 22, 2021
2:00 pm-3:30 pm Eastern/11:00 am-12:30 pm Pacific

Richard McCallum HOW TO WRITE A MANUSCRIPT (PART 2): RESULTS & CONCLUSIONS
Richard McCallum
Editor-in-Chief, Journal of Investigative Medicine

Learn more and register

Virtual Education Series

 
Join the AFMR Social Media Team

AFMR is taking its social media footprint to the next level AFMR is taking its social media footprint to the next level.

We need social media savvy members to help us promote AFMR national and regional news and events, our journals, and member news.

Become a member of the new AFMR Social Media Committee, chaired by Ricardo Correa, MD, AFMR Western chair elect. We’re looking for representation for all AFMR regions.

As a social media committee member, you’ll help plan the AFMR social media approach and be part of the posting team for one of the AFMR platforms (Twitter, LinkedIn and Facebook). And your participation in a national-level AFMR committee will be a good addition to your resume!

Send us an email if you're interested.

 
View the AFMR Regional Meeting Highlights Online

AFMR members can now view the full programs and presentations from the Southern and Western regional meetings on the AFMR website. Access is free.

Registration is required. Those who have already registered for a Virtual Education Portal presentation only need to log in. The meeting videos are compatible with mobile devices, tablets, laptops and desktops.

View the Western Medical Research Conference proceedings.
Western Medical Research Conference

View the Southern Regional Meeting proceedings.
Southern Regional Meeting

Coming Soon
The programs/presentations for the Eastern Regional and Midwest Clinical and Translational Research meetings will be uploaded soon. Check back later in June to view the content.

 
Save the Dates: 2022 Regional & National Meetings

American Federation for Medical Research

2022 Regional Meetings
AFMR regional councils are beginning to plan 2022 meetings. Western and Southern event dates have been set. Others are still to be determined.

Western Medical Research Conference
January 20-22, 2022
Carmel, CA

Southern Regional Meeting
February 10-12, 2022
February 2-4, 2023
New Orleans, LA

Eastern Regional Meeting
TBD

Midwestern Clinical and Translational Research Meeting
Date TBD
Chicago, IL

2022 National Meetings

Experimental Biology
April 2-5, 2022
Philadelphia, PA

Translational Science
TBD
Washington, DC

 
Articles in Nature and The Lancet Raise Concerns About How COVID-19 Has Exposed Shortfalls in Global Clinical Research

nature

Two recent publications have detailed the negative effect that COVID-19 has had on global clinical research. These concerns include the registration of clinical trials with “questionable” methodological quality, revealing weaknesses in the current system.

"How COVID Broke the Evidence Pipeline" was published in Nature on May 12, 2021.
The author states that the pandemic provided a stress test for global production of medical evidence, exposing the flaws of the current system. Areas covered in the piece include:

Read the article.


The Lancet "How COVID-19 Has Fundamentally Changed Clinical Research in Global Health" appeared in The Lancet in May 2021, the fourth in a series of papers on clinical trials in global health. The authors conclude that the response to the pandemic:

Read the article.

In June 2020, current National Council member and publications committee chair John Dickinson, MD interviewed Andre Kalil, MD, University of Nebraska, about the issue of well-designed trials. Listen to the podcast.

 
FASEB Releases New Report on Shared Research Resources

FASEB

In May, FASEB released the final report of its Shared Research Resources (SRRs) Task Force, Maximizing Shared Research Resources —Part III: Addressing Systemic Challenges and Opportunities — outlining strategies to improve SRR recognition and sustainability. It builds on Parts I and II of the report, showing the value of SRRs to the world of research.

Shared resources, found at institution core facilities, "...provide efficient and widespread access to cutting-edge technologies and scientific expertise," according to an article in FASEB's The Washington Update.

The task force identified five (5) fundamental objectives that are key to advancing SRRs and their impact on the progress of biomedical research:

Read the article.

View the final Part III report.

Read Parts I (Recommendations) and II (Survey Findings).

 
In the New York Times: "From the Wastewater Drain, Solid Pandemic Data"

New York Times

A May 7th article in The New York Times detailed the collection and analysis of wastewater to identify and track the coronavirus. Such research has moved the field of wastewater epidemiology from a "niche" area to one that may become a "...mainstream public health practice."

The article details how this sewage surveillance has been used in the US and around the world.

Read the article.

 
From Science: "Hybrid Scientific Conferences Aim to Offer the Best of In-person and Virtual Meetings"

Science

A May article in Science discusses how some US societies are experimenting with hybrid scientific meetings — combining in-person and virtual elements — as the coronavirus pandemic recedes in the United States.

The piece details the complexity and cost of putting together such events. (The article was published before the CDC’s new guidelines on mask wearing) and whether potential success of hybrid meetings will create a new model for scientific conferences of the future.

Read the article.

 
Research!America Survey: Most Americans Can't Name a Living Scientist or Research Institution

Research!America

AFMR is a member of Research!America, which advocates for "science, discovery, and innovation to achieve better health of all."

One way Research!America keeps its finger on the pulse of the attitudes and concerns of laypeople about medical research is through regular public opinion polls.

A January 2021 poll determined that most Americans (72 percent) are unable to name a living scientist, over half cannot name a medical or health research institution, and 43 percent did not know that medical research is conducted throughout all 50 states.

View the poll.

 
Join the AFMR Conversation: Connect on Twitter & LinkedIn

AFMR Research

AFMR Research
Journal of Investigative Medicine

Journal of Investigative Medicine

On LinkedIn

American Federation for Medical Research

American Federation for Medical Research

 
AFMR Publication Highlights

Journal of Investigative Medicine (JIM)

Journal of Investigative Medicine (JIM)

As of January 2021, JIM is an online only journal.

Announcing JIM's COVID Collection: Articles from the JIM archive on pandemic-related research.

Podcast
Thrombosis and Anticoagulants — Inpatient and Outpatient
Guest: Mateo Porres-Aguilar, MD, Texas Tech University Health Sciences Center, El Paso, TX
May 28, 2021

Editorial
Fauci effect? When the heart is in the right place, but reality is not
Jorge Cervantes
http://dx.doi.org/10.1136/jim-2021-001949

Original Research
Editor's Choice
Lung involvement in systemic sclerosis is associated with adverse hospital outcomes: insights from the National Inpatient Sample
Jesse Osemudiamen Odion, Armaan Guraya, Chukwudi Charles Muojieje, Osahon Nekpen Idolor, Eseosa Jennifer Sanwo, Osaigbokan Paul Aihie
http://dx.doi.org/10.1136/jim-2020-001743

Behavioral health clinicians endorse stellate ganglion block as a valuable intervention in the treatment of trauma-related disorders
James H Lynch, Peter D Muench, John C Okiishi, Gary E Means, Sean W Mulvaney
http://dx.doi.org/10.1136/jim-2020-001693

Insulin doses requirements in patients with type 1 diabetes using glargine U300 or degludec in routine clinical practice
Florentino Carral San Laureano, Mariana Tomé Fernández-Ladreda, Ana Isabel Jiménez Millán, Concepción García Calzado, María del Carmen Ayala Ortega
http://dx.doi.org/10.1136/jim-2020-001633

Association between the use of antidepressants and the risk of preterm birth among pregnant women with depression: a retrospective cohort study in Taiwan
Li-Fen Chen, Ching-En Lin, Chi-Hsiang Chung, Ching-Huang Lai, Wu-Chien Chien
http://dx.doi.org/10.1136/jim-2020-001683

Hemogram as marker of in-hospital mortality in COVID-19
Alejandro López-Escobar, Rodrigo Madurga, José María Castellano, Santiago Ruiz de Aguiar, Sara Velázquez, Marina Bucar, Sara Jimeno, Paula Sol Ventura
https://bmj.com/coronavirus/usage
http://dx.doi.org/10.1136/jim-2021-001810

Impact of coexisting pneumonia in the patients admitted with Clostridium difficile infection: a retrospective study from a national inpatient database
Asim Kichloo, Zain El-Amir, Dushyant Singh Dahiya, Jagmeet Singh, Dhanshree Solanki, Farah Wani, Hafeez Shaka
http://dx.doi.org/10.1136/jim-2021-001820

Brief Reports
Thoughtful selection and use of scientific terms in clinical research: the case of ‘pragmatic’ trials
Rafael Dal-Ré, Robert J Mentz, Frits R Rosendaal
http://dx.doi.org/10.1136/jim-2021-001789

2021 Midwest Clinical and Translational Meeting of CSCTR and MWAFMR

Abstracts
http://dx.doi.org/10.1136/jim-2021-MW

Author Index
http://dx.doi.org/10.1136/jim-2021-MW.authorindex


Journal of Investigative Medicine High Impact Case Reports (JIM-HICR)

JIM — High Impact Case Reports

Check out JIM-HICR's new COVID-19 Collection of cases focusing on pandemic-related issues.

Recurrent Colon Cancer: Presentation with Disseminated Intravascular Coagulation from Disseminated Carcinomatosis of the Bone Marrow
Diffuse carcinomatosis of the bone marrow (DCBM) is a rare clinical condition characterized by diffuse bone marrow involvement with hematological changes. This case study concerns a patient who presented with DCBM secondary to colon cancer with diffuse intravascular coagulation. This is a rare presentation of DCBM in colon cancer. The case study also elaborates on clinical features, pathogenesis, and therapy of this unique presentation.

Severe Liver Injury Associated with High-Dose Atorvastatin Therapy
Statins are recommended for first-line management of elevated cholesterol in the primary and secondary prevention of atherosclerotic cardiovascular disease. Statins may occasionally be associated with mild transaminase elevations but can also result in life-threatening liver injury. Atorvastatin is the most common cause of clinically significant liver injury in this drug class. We report a case of severe, asymptomatic liver injury in a hepatocellular pattern in a 71-year-old man occurring within 3 months of switching from simvastatin to high-intensity atorvastatin therapy. Hepatitis improved rapidly with cessation of atorvastatin and did not recur after resuming simvastatin.

Primary Pulmonary Artery Sarcoma Confined to the Left Pulmonary Artery
Primary pulmonary artery sarcomas (PPAS) are extremely rare tumors that are often mislabeled as pulmonary emboli (PE). PPAS usually involve the pulmonary trunk and are histologically classified as leiomyosarcoma, spindle cells sarcoma, fibrous histiocytoma, or undifferentiated sarcoma. Our case involved a 78-year-old man with an undifferentiated PPAS confined to the left pulmonary artery that was initially misdiagnosed as a PE. After a month-long delay in treatment in which the patient was prescribed warfarin, the correct diagnosis was made. Pulmonary artery endarterectomy and left lung pneumonectomy were performed, and he survived for 18 months before disease recurrence and death. Our case helps illustrate some of the clinical and radiographic findings that help distinguish PPAS from PE.

Factitious Disorder Masquerading as a Life-Threatening Anaphylaxis (March 2021/Popular on Figure 1)
Factitious disorder is a psychiatric disorder in which sufferers intentionally fabricate physical or psychological symptoms in order to assume the role of the patient, without any obvious gain. We present a case of a 23-year-old female with chronic urticaria who presented with dyspnea, dysphasia, mild generalized erythema, abdominal cramps, and headache. She was tachypneic and hypotensive. This was her third admission with similar symptoms within the last 7 months. Tryptase, complement, anti-SM/RNP, Sjogren, Scl-70, C3, and C4 were negative. Computed tomography–guided bone marrow biopsy showed no mast cells. Flow cytometry did not show any immunophenotypic reaction. Other possible differentials including pregnancy, autoimmune disorders, and infections including hepatitis, thyroid disorder, and age-related malignancies were ruled out. After a thorough review, malingering disorder was ruled out, but we noticed the patient’s intent of assuming a sick role. Later, the patient was diagnosed with major depressive disorder. Factitious anaphylaxis can present with multiple presentations including a life-threatening condition that mimics true anaphylaxis. A better approach would be thorough clinical evaluation and early multidisciplinary involvement. This case highlights the importance of further evidence-based studies in factitious disorder to decrease the disease burden and reduce the health care cost.

 
Global Research on Coronavirus

World Health Organization (WHO)

The World Health Organization (WHO) has a dedicated page devoted to global research on coronavirus.

The page includes links to:

 
Updates on COVID Therapeutics/Vaccine Research

COVID-19

Latest updates:

Therapeutics

Vaccines

 
Johns Hopkins Coronavirus Research Center

News and information on COVID-19 is constantly changing.

The Johns Hopkins coronavirus resource center now includes a vaccine tracker, as well as separate pages covering:

Its Interactive Map is updated throughout the day.
COVID-19 Interactive Map 2021

 
AFMR 2022 Meetings

AFMR 2022 meetings are currently in the planning stages.

Visit the AFMR website to get the latest updates on 2022 AFMR meetings and events.
Theo Trandafirescu, MD, VP of Meetings & Programs
Theo Trandafirescu, MD
VP of Meetings & Programs