|AFMR Website||Meetings/Events Calendar||Submit a JIM manuscript|
Janice P. Dutcher, MD
Thank you for all you do to provide healthcare to your patients and for your work to further science.
AFMR 2021 Budget: The National Council reviewed and approved the AFMR 2021 budget at its December meeting. The organization’s financial management has been and continues to be very responsible. Even though revenues have been affected by the pandemic, we remain optimistic. This year, all regional meetings will be virtual and, therefore, revenue neutral. More
The deadline to apply for the 2021 AFMR National Awards is fast approaching — January 15th.
Both awards are open to current AFMR members:
Prior to applying, determine the status of your AFMR membership to ensure your eligibility.
Awards are usually presented in-person at the Translational Science Meeting in Washington, DC, which will be virtual this year.
The 2021 honors will be bestowed during a virtual awards ceremony during which the winners will present their research. More
Regional Meetings in the Time of Coronavirus
AFMR regional leadership and staff are meeting the challenge of the coronavirus pandemic, working hard to plan virtual meetings for 2021. Our goal is to provide AFMR members with the opportunity to experience the same high-quality level of scientific presentations virtually.
The new year will begin with the Western Medical Research Conference at the end of January.
On Friday, January 29, the event will run from 8:00 am to 5:15 PST. Saturday will go from 8:00 am to 2:50 pm PST. Check out the preliminary program.
Each time slot will offer attendees a choice of presentations grouped by subject matter. In addition, there will be an awards presentation and talk on Friday, as well as the WSPR Stanley Wright Lecture on Diversity given by AFMR National Council member Ricardo Correa, MD of the University of Arizona College of Medicine in Phoenix.
Next up will be the Southern Regional Meeting at the end of February.
The Southern Regional Meeting is co-sponsored by SAFMR, Academic Pediatric Association, Southern Society for Clinical Investigation (SSCI), Southern Society for General Internal Medicine, and Southern Society for Pediatric Research.
The preliminary program is now online.
The event will span three days —Thursday, February 25 from 11:00 am to 6:30 pm CST, Friday, February 26 from 9:00 am to 6:00 pm CST, and Saturday, February 27 from 9:00 am to 2:00 pm CST.
Everyone is eligible to submit to the event, which will be virtual due to uncertainties of the COVID 19 pandemic.
Join AFMR to be eligible for awards.
Johns Hopkins has added a vaccine tracker to its Coronavirus Research Center.
Its map shows which states are providing public data regarding administration of COVID19 vaccines. At press time, a little over 35 states were making data available.
Four Duke scholars discussed logistics, vaccinating children and inequities between rich and poorer nations during a media briefing on December 3, 2020.
Participants included: Thomas Denny (COO, Duke Human Vaccine Institute), Arti Rai (law professor), Gavin Yamey, MD (professor of the practice, global health and public policy), and David McAdams (business administration professor).
Don't miss the latest offering in the AFMR Virtual Education Series — "Becoming a Physician Scientist: How to Incorporate Research into Your Medical Training & Career."
The program was presented in early December by AFMR National Council member & Western Region chair-elect Melanie Cree-Green, MD, PhD and Shanlee Davis, MD, MSCS of the University of Colorado - Anschutz Medical Campus. The webinar covered career tips and advice for individuals in the field ranging from those in medical training through mid-career faculty. There was a special emphasis on issues facing women researchers.
The presentation can be viewed in the Virtual Education Series Archives on the AFMR website. Archived webinars are available to AFMR members and the general public alike. Registration is necessary to access the content.
Other archived presentations include:
The new year will bring more interesting Virtual Education Series content. Check your email and the newsletter for 2021 offerings.
FASEB recently met with Biden-Harris Transition Team members, following up with a memo highlighting 10 priority policy recommendations for promoting the advancement of science and encouraging innovation.
||Journal of Investigative Medicine
|American Federation for Medical Research
As of January 2021, JIM is an online only journal.
The End of the Beginning: A Transition to the "Brave New World"
Richard W. McCallum
Impact of comorbidities on clinical prognosis in 1280 patients with different types of COVID-19
Huilin Fang, Qiaomei Liu, Maomao Xi, Di Xiong, Jing He, Pengcheng Luo, Zhanghua Li
Efficacy of patent foramen ovale closure for treating migraine: a prospective follow-up study
Yi Qi, Yushun Zhang, Xiaohui Luo, Gesheng Cheng, Yajuan Du, Rui Liu, Hui Xie, Yawen Cheng, Yichen Guo, Guogang Luo
Evaluating the added predictive ability of MMP-9 in serum for Kawasaki disease with coronary artery lesions
Lixia Wang, Yinan Yang, Quanmiao Cui, Ya Cui, Qiaoe Li, Xinyao Che, Cong Wang, Peiqin Quan, Xiaobin Hu
In vitro interaction of fluconazole and trimethoprim–sulfamethoxazole against Candida auris using ETEST and checkerboard methods
Heather R Davis, Deborah S Ashcraft, George A Pankey
Faculty Development & Education
Emerging clinical scientist paradigm: a call for spectrum recognition in team science
Gailen D Marshall
Letter to the Editor
Proposal of a scale for COVID-19 stigma-discrimination toward health workers
Adalberto Campo-Arias, Isabel Álvarez-Solorza, Andrés Felipe Tirado-Otálvaro, Carlos Arturo Cassiani-Miranda
2021 Western Medical Research Conference
Check out JIM-HICR's new COVID-19 Collection of cases focusing on pandemic-related issues.
Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case Series
The novel SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2) is now known to cause acute respiratory distress, cytokine storm, and coagulopathy. Multiple other manifestations have been published in recent literature. Rhabdomyolysis is a syndrome of muscle damage, with release of intracellular contents into circulation. It is characterized by marked elevations of creatinine kinase levels and myoglobinuria. In this article, we describe a series of 5 cases who were admitted with COVID-19 pneumonia and had severe muscle injury, as demonstrated by significant elevation (>5 times upper limit of normal) of creatinine kinase levels likely secondary to SARS-CoV-2 virus. The median age for these patients was 65 years, and most of them suffered from diabetes and hyperlipidemia. All patients were hypertensive males. Four out of 5 patients had preserved kidney function at baseline and were chronic kidney disease (CKD) stage 2 or better. However, most of them suffered significant kidney injury and at the time of discharge one patient was CKD stage 2 or better, 2 were CKD stage 3 or worse, and 2 patients had renal failure and died due to complications of SARS-CoV-2 infection.
Acute Respiratory Failure from Hypermagnesemia Requiring Prolonged Mechanical Ventilation
Electrolyte abnormalities are an underrecognized cause of respiratory failure in the intensive care unit. One such abnormality is a relatively rare phenomenon of hypermagnesemia resulting in paralysis. A 73-year-old Caucasian male patient presented to the emergency department with diffuse abdominal pain of 2-day duration. He received magnesium citrate and gastrointestinal cocktail for his constipation after initial imaging showed constipation. In view of acute worsening, follow-up computed tomography of the abdomen was done, which showed free air in upper abdomen along with free fluid. Hence, he was taken for emergent laparotomy with repair of pyloric ulcer perforation with omental patch. Post procedure course was complicated by sepsis, acute kidney injury, and respiratory failure with hypoxemia and hypercapnia. On physical examination the patient had flaccid paralysis in all his extremities along with absent brain stem reflexes. Extensive workup including imaging of brain failed to reveal diagnosis. On postoperative day 1, the patient was noted to have magnesium level of 9.2 mg/dL (1.6-2.3 mg/dL), which was thought to be cause of flaccid paralysis and respiratory failure. In view of his acute oliguric kidney injury, he was initiated on intermittent hemodialysis, until his magnesium levels were back to its physiologic limits. His paralysis gradually improved over next 48 to 72 hours and he was liberated from ventilator successfully.
Aggressive Diffuse Intermediate Size B-Cell Lymphoma with P53 Mutation Presented as Primary Bone Marrow Lymphoma
Primary bone marrow lymphoma (PBML) is a disease entity in which lymphoma primarily originates in the bone marrow without signs of involvement of lymph nodes, spleen, liver, or any other organs, and excludes leukemia/lymphoma. PBML has been a rare presentation of malignant lymphoma, and most of the cases have a poor prognosis and require rapid diagnoses and treatments. Among all PBMLs, diffuse large B-cell lymphoma (DLBCL) is the most common pathological subtype. Over 25 years and from 7 institutions, the International Extranodal Lymphoma Study Group retrospectively collected PBML cases and, in 2012, published these 21 cases, including 19 cases of B-cell lymphoma and 2 cases of peripheral T-cell lymphoma. Among the B-cell types, DLBCL accounted for 79% and follicular lymphoma (FL) for 21%. DLBCLs were characterized by the existence of large cells. In this article, we present a rare case of high-grade aggressive type with P53 mutation, intermediate-sized B-cell lymphoma, excluded FL by the absence of FL lymphoma markers, presented as PBML. Our patient had rapid progression and succumbed to the disease shortly after diagnosis. Upon literature review, 62 B-cell lymphoma cases were identified that presented as PBML (51 high-grade and 11 low-grade)—mostly case reports. Among these, only one case was reported as intermediate-sized DLBCL-like lymphoma but not with aggressive features. Our case represents the first case of aggressive intermediate-sized lymphoma, not a FL, with P53 mutation, highly elevated lactate dehydrogenase, and Ki-67 presented as PBML. Such a profile would need to be quickly recognized and aggressive treatment applied, such as CART (chimeric antigen receptor T-cells) therapy or DA-EPOCH-R (dose-adjusted EPOCH [etoposide-prednisone-oncovin-cyclophosphamide-hydroxydaunorubicin] and rituximab) with or without venetoclax.
The NIH Coronavirus Disease 2019 (COVID-19): Information for NIH Applicants and Recipients of NIH Fund page offers a wide range of guidance on research funding.
|The Guidance portion includes the following sections:
||In the Funding section, there are two sections:
The World Health Organization (WHO) has a dedicated page devoted to global research on coronavirus.
News and information on COVID-19 is constantly changing.
The Johns Hopkins coronavirus resource center now includes a vaccine tracker, as well as separate pages covering:
Its Interactive Map is updated throughout the day.
|All 2021 AFMR Regional and Affiliate meetings will be virtual. Dates are listed below in chronological order.
Visit the AFMR website to get the latest updates on 2021 AFMR meetings and events.
Cherry Wongtrakool, MD
VP of Meetings & Programs
Western Regional Meeting
January 29-30, 2021
Southern Regional Meeting
February 25-27, 2021
Translational Science 2021
March 30, 2021-April 2, 2021
Eastern Regional Meeting
April 2, 2021
Late Breaking Abstracts Now Accepted Until January 31, 2021.
Midwest Clinical & Translational Research Meeting
April 8-9, 2021
Abstract Deadline: January 17, 2021
Experimental Biology 2021
April 27-30, 2021