Volume II, Issue 2: February 2021
American Federation for Medical Research (AFMR) Insights
AFMR Website Meetings/Events Calendar Submit a JIM manuscript Follow AFMR on Twitter
IN THIS ISSUE

 

Janice P. Dutcher, MD, AFMR President
Janice P. Dutcher, MD
AFMR President
Since COVID-19 upended all of our lives last winter, AFMR has strived to continue providing members with programming — albeit virtually.

In 2020, we created the Virtual Education Portal to bring presentations and research to everyone at home. It currently includes the 2020 Virtual Awards Ceremony, Eastern and Midwestern regional meeting presentations, podcasts, and the Virtual Education Series of informational webinars.

In 2021, all AFMR regional meetings will be virtual. Members can attend online, and, if they cannot attend, view the proceedings online on the Virtual Education Portal of the AFMR website. Registration will be required for those who haven’t already done so.

None of this would have been possible without the work of AFMR leadership, on both the regional and national levels, with the support of staff and technical know-how of the web team. More

 
Journal of Investigative Medicine (JIM) Now Being Published Online Only

Journal of Investigative Medicine (JIM)
As of 2021, the Journal of Investigative Medicine (JIM) — AFMR's peer-reviewed journal — is being published online only.

AFMR members can access their subscriptions by going to the Members Only section of the AFMR website.

Virtual Abstract Supplements

Abstract supplements are now available to all for the following meetings:

Members can also read archived journals by clicking "View past issues."

AFMR members in good standing receive free access to JIM.

In addition, there are no page charges for member manuscripts published in the journal.

Check your membership status online.

 
Register Today for CME Accredited Southern Regional Meeting: February 25-27

The Southern Regional Meeting is going virtual for 2021. The event dates are Thursday, February 25th - Saturday, February 27th.

The event is co-sponsored by the Academic Pediatric Association, Southern Society for Clinical Investigation, and Southern Society for Pediatric.

Southern Regional Meeting

The meeting will include:

CME Certification
CME certification is provided by the Center of Continuing Education, Tulane University Health Sciences Center. Tulane University Health Sciences Center designates this live activity for a maximum of 16 AMA PRA Category 1 Credits™.

Registration Fees
Member: $65
Non-member: $75
Trainee/student: $55
CME Certification of Credit: $50

Learn more and register!

 
Congratulations to Western Regional Meeting Award Recipients!

The Western Regional Medical Research conference took place virtually from January 29th - 30th.

Honors included the AFMR Henry Christian Award, as well as Western AFMR subspecialty awards.

Honorees included:

AFMR HENRY CHRISTIAN AWARD RECIPIENT

Geoanna Bautista SMOOTH MUSCLE CELL PIEZO1 IN SMALL BOWEL CONTRACTILITY AND GROWTH
Geoanna Bautista
University of California Los Angeles

View the full list of awardees

 
Coming Soon Online: View the Western Regional Meeting Sessions

The 2021 Western Medical Research Conference took place from January 29th -January 30th, sponsored by WAFMR and the Western Society for Pediatrics Research (WSPR).

Each time slot offered attendees a choice of presentations grouped by subject matter. In addition, there was an awards presentation and talk on Friday, as well as the WSPR Stanley Wright Lecture on Diversity given by AFMR National Council member Ricardo Correa, MD of the University of Arizona College of Medicine in Phoenix. Dr. Correa is secretary-treasurer of the AFMR Western Regional Council.

The entire proceedings will be available free to all online on the Virtual Education Portal and Western Section pages of the AFMR website. Registration will be required for those who haven’t already done so.

Western Regional Meeting

 
British Medical Journal Article Calls for International Collaboration to Ensure Fair, Equitable COVID Vaccine Distribution

British Medical Journal

An article published in The British Medical Journal on January 5, 2021 states that international collaboration is “…key for the fair and efficient distribution of COVID-19 vaccines,” recommending a Fair Priority Model over Covax’s proposed proportional allocation based on population.

The article authors include Lisa M. Herzog, University of Groningen, Netherlands; Ole F. Norheim, University of Bergen, Norway; Ezekiel J Emanuel, Perelman School of Medicine, University of Pennsylvania; and Matthew S. McCoy, Perelman School of Medicine, University of Pennsylvania.

Read the article.

 
Post COVID/Long COVID: Curated Review of Key Information & Literature

Post COVID/Long COVID: Curated Review of Key Information & Literature

The CDC and Infectious Diseases Society of America (IDSA) offers a curated review of key information and literature about Post COVID/Long COVID online — including an overview, key literature and resources. It is part of the COVID-19 Real-Time Learning Network.

The information is updated regularly.

 
FASEB Provides Current Data on NIH Funding Levels, Grant Awards & Application Success Rates

FASEB

FASEB releases a "National Institutes of Health (NIH) Appropriations & Grant Trends" analysis annually. The document provides the most up-to-date data on NIH funding levels, grant awards and application success rates.

Information for this year's breakdown was drawn from the NIH RePORTER database, covering fiscal years 2010-2020. The analysis also includes FY 2021 budget recommendations from the Trump administration.

Read background about and view the data.

 
Research!America Offers Recordings of Recent Webinars on COVID-Related Issues

Research!America

Last year, AFMR initiated a partnership with Research!America — an alliance advocating for science, discovery and innovation.

AFMR regularly publicizes events hosted by Research!America available to our members.

Several recent events are now archived:

 
Join the AFMR Conversation: Connect on Twitter & LinkedIn

AFMR Research

AFMR Research
Journal of Investigative Medicine

Journal of Investigative Medicine

On LinkedIn

American Federation for Medical Research

American Federation for Medical Research

 
AFMR Publications Highlights

Journal of Investigative Medicine (JIM)

Journal of Investigative Medicine (JIM)

As of January 2021, JIM is an online only journal.

Podcasts

Thyroid Awareness Month with Tamis Bright
Guest: Tamis Bright, MD, Texas Tech University Health Sciences Center El Paso
January 20, 2021

HIV Awareness Month with Stephanie Baer
Guest: Stephanie Baer, MD, Chief of Infection Control and Epidemiology, Charlie Norwood VA Medical Center, Augusta, GA
December 16, 2020

Editorial

'Wisdom in the time of COVID-19'
Everardo Cobos, Glenn Goldis, Richard McCallum
10.1136/jim-2020-001777

Original Research

Association between goal-striving stress and rapid kidney function decline among African Americans: the Jackson Heart Study
Loretta Cain-Shields, LáShauntá Glover, Bessie Young, Mario Sims
10.1136/jim-2020-001510

Linkage to specialty care in the hepatitis C care cascade
Dena P Blanding, William P Moran, John Bian, Jingwen Zhang, Justin Marsden, Patrick D Mauldin, Don C Rockey, Andrew D Schreiner
10.1136/jim-2020-001521

Incidentally detected acromegaly: single-center study of surgically treated patients over 22 years
Erica Alexandra Giraldi, Emir Veledar, Nelson M Oyesiku, Adriana G Ioachimescu
10.1136/jim-2020-001605

In-hospital outcomes and prevalence of comorbidities in patients with infective endocarditis with and without heart blocks: Insight from the National Inpatient Sample
Shakeel M Jamal, Asim Kichloo, Michael Albosta, Beth Bailey, Jagmeet Singh, Farah Wani, Muhammad Shah Zaib, Muhammad Ahmad, Muhammad Dilawar Khan, Ronak Soni, Michael Aljadah, Hafiz Waqas Khan, Mahin Khan, Muhammad Z Khan
10.1136/jim-2020-001501

Brief Reports

Use of white cell count, age, and presence of other injuries in stratifying risk of intracranial injury in pediatric trauma
Margo A Peyton, Theodore Kouo, Jennifer Scott, Lisa R Yanek, Thuy L Ngo
10.1136/jim-2020-001509

Determinants of pre-exposure prophylaxis (PrEP) persistence in a high-risk population in Central Florida
Jonathan Keyes, Eloisa Catherine Crouse, Edwin DeJesus, Charlotte-Paige Rolle
10.1136/jim-2020-001352

2021 Southern Medical Research Conference

Award Recipients
10.1136/jim-2021-SRMC.award

Abstracts
10.1136/jim-2021-SRMC


Journal of Investigative Medicine High Impact Case Reports (JIM-HICR)

JIM — High Impact Case Reports

Check out JIM-HICR's new COVID-19 Collection of cases focusing on pandemic-related issues.

Successful Long-Term Control of the Syndrome of Episodic Angioedema with Eosinophilia (Gleich Syndrome) With Low-Dose Imatinib Mesylate and Prednisone
The syndrome of episodic angioedema with eosinophilia, first reported over 40 years ago, is a hypereosinophilic disorder that, uniquely, is not associated with end-organ pathology. However, patients develop a constellation of symptoms that include angioedema, urticaria, fatigue, and fever. Episodes are accompanied by massive hypereosinophilia and weight gain. Type II serum cytokine levels (IL-5, IL-13, IL-9, and IL-10) show cyclic variations peaking at or just prior to the peak of eosinophilia and an abnormal Th2 cell phenotype has been reported. Attacks may occur with predictable regularity and have been described in both adults and children. Glucocorticoid therapy reliably reverses symptoms with accompanying diuresis, defervesce, and normalization of the eosinophil count. In this report, a patient who had the syndrome of episodic angioedema with eosinophilia exceeding 20 years is reported. He has had no end-organ damage to date. Testing for the CHIC2 deletion, a surrogate for the FIP1L1-PDGFRA fusion, was negative. Use of imatinib mesylate, initially as a steroid-sparing agent, and subsequently as a maintenance medication, plus low-dose prednisone has provided long-term control of hypereosinophilia and all clinical manifestations.

Psuedo-Cor Triatriatum in an Elderly Patient with Dyspnea of Exertion: An Undescribed Condition Characterized by 3-Dimensional Transesophageal Echocardiography
A 66-year-old gentleman with no prior cardiac history presented with dyspnea on exertion and chest pain for 1 month. His workup included a transthoracic echocardiogram, which demonstrated findings suggestive of cor triatriatum (C-TAT) with uncertain degree of hemodynamic obstruction. In addition, mild left ventricular systolic dysfunction and segmental wall motion abnormalities suggestive of coronary artery disease were noted. The patient then underwent transesophageal echocardiography (TEE) to define better the structural characteristics and hemodynamic significance of the C-TAT, left and right heart catheterization to assess pressure gradients between the upper and lower left atrial chambers by simultaneous measurement of pulmonary capillary wedge and left ventricular end-diastolic pressures, and coronary angiography. Multiplane 2-dimensional TEE demonstrated an atrial membrane extending from the inferior portion of the interatrial septum to the superior aspect of the lateral atrial wall. This membrane exhibited a medial large oval opening with bidirectional flow and a ≤2 mm Hg gradient. Three-dimensional TEE imaging re-demonstrated this obliquely oriented membrane; however, of most importance, it revealed that the membrane divided the atria into a medial funnel and C-shaped cavity with a large distal oval shape opening and an even larger lateral atrial cavity. These findings were inconsistent with a true C-TAT and rather demonstrated what we defined as a pseudo-C-TAT membrane. Simultaneous right and left heart catheterization confirmed a minimal gradient of 3 to 5 mm Hg and coronary angiography demonstrated severe 3-vessel coronary disease as the primary cause of the patient’s clinical syndrome.

Electrolyte Replacement in Bartter Syndrome with Abnormal Small Bowel: A Case Report
Bartter syndrome is a rare disorder that is characterized by weakness and fatigue with laboratory findings of hypokalemia and metabolic alkalosis with increased aldosterone and angiotensin. It specifically acts on the ascending loop of Henle, characterized by miscoded proteins affecting NaCl transports and channels. Patients will require replacement of potassium and sometimes magnesium due to the kidneys’ inability to reabsorb these ions. So what happens when the body’s other primary mechanism of absorption of these elements are taken out? In this article, we present the case of a 47-year-old woman with Bartter syndrome on oral potassium 40 mg BID (twice a day) and magnesium oxide 800 TID (thrice a day), who recently had a small bowel resection that required intravenous potassium and magnesium throughout her hospital admission. Significant questions arose as to how her electrolytes should be managed, given her unusual presentation with rare underlying disorder. We discuss the implications of her bowel resection in the context of Bartter syndrome and our views on her future course based on available literature.

 
NIH Grants & Funding: Coronavirus Disease 2019

NIH

The NIH Coronavirus Disease 2019 (COVID-19): Information for NIH Applicants and Recipients of NIH Fund page offers a wide range of guidance on research funding.

The Guidance portion includes the following sections:
  • Overview presentation (in PowerPoint and Word formats)
  • Proposal Submission & Award Management
  • Human Subjects & Clinical Trials
  • Animal Welfare
  • Peer Review
  • FAQs (last updated April 13, 2020)
In the Funding section, there are two sections:
  • Blog: COVID-19 Funding and Funding Opportunities
  • List of NIH Funding Opportunities Specific to COVID-19

Learn more.

 
Global Research on Coronavirus

World Health Organization (WHO)

The World Health Organization (WHO) has a dedicated page devoted to global research on coronavirus.

Elements include:

Related documents: Ethics and COVID-19: Resource allocation and priority setting

 
Updates on COVID Therapeutics/Vaccine Research

COVID-19

Latest updates:

Therapeutics

Vaccines

 
Johns Hopkins Coronavirus Research Center

News and information on COVID-19 is constantly changing.

The Johns Hopkins coronavirus resource center now includes a vaccine tracker, as well as separate pages covering:

Its Interactive Map is updated throughout the day.
COVID-19 Interactive Map 2021

 
AFMR 2021 Meeting Dates Set

All 2021 AFMR Regional and Affiliate meetings will be virtual. Dates are listed below in chronological order.

Visit the AFMR website to get the latest updates on 2021 AFMR meetings and events.
Cherry Wongtrakool, MD, VP of Meetings & Programs
Cherry Wongtrakool, MD
VP of Meetings & Programs

February 2021
Southern Regional Meeting
Southern Regional Meeting
February 25-27, 2021
March 2021
Translational Science 2021
Translational Science 2021
March 30, 2021-April 2, 2021
April 2021
Eastern Regional Meeting
Eastern Regional Meeting
April 2, 2021
Late Breaking Abstracts Now Accepted Until January 31, 2021.
Midwest Clinical & Translational Research Meeting
Midwest Clinical & Translational Research Meeting
April 8-9, 2021
Abstract Deadline: January 17, 2021
Experimental Biology
Experimental Biology 2021
April 27-30, 2021