Volume I, Issue 8: September 2020
American Federation for Medical Research (AFMR) Insights
AFMR Website Meetings/Events Calendar Submit a JIM manuscript Follow AFMR on Twitter
IN THIS ISSUE

 

Janice P. Dutcher, MD, AFMR President
Janice P. Dutcher, MD
AFMR President
I am pleased to announce that Lora Kasselman, MPH, PhD has been appointed to the position of AFMR Eastern Regional Chair-elect. The position remained vacant after the recent AFMR elections. Dr. Kasselman was recommended by National Council member Alison Reiss, and the appointment was approved by the National Council.

Dr. Kasselman is an Assistant Professor in the Department of Foundations of Medicine at New York University (NYU) Long Island School of Medicine. She also is a researcher at NYU Long Island School of Medicine and the City University of New York (CUNY). She has participated in numerous AFMR Eastern Regional meetings. More

 

American Federation for Medical Research

AFMR is launching an initiative to provide members with virtual educational opportunities during the coronavirus pandemic.

With in-person meetings being cancelled or in limbo, AFMR will be offering a range of events from workshops to symposia to abstract/journal review sessions. The hope is that these offerings will continue once in-person meetings return, providing educational opportunities online. More

 
Updates on COVID Therapeutics/Vaccine Research

COVID-19 Researchers around the world are racing to develop therapeutics and vaccines aimed at stemming the coronavirus pandemic.

Some updates:

Therapeutics

Vaccines

 

AFMR congratulates the Journal of Investigative Medicine (JIM) on its 2019 high impact factor numbers — 2.304 (Journal Citation Reports, Clarivate Analytics) — the highest in four (4) years.

JIM ranked 60/165 in the Medicine, General and Internal categories. More

 
Submit Abstracts Today for Western & Southern Regional Meetings

Deadlines are approaching to submit your abstracts to the 2021 Western Medical Research Conference and Southern Regional Meeting.

Everyone is eligible to submit abstracts to these two events, which will be virtual due to uncertainties of the COVID 19 pandemic. Join AFMR to be eligible for awards.

Western Regional Meeting
Western Medical Research Conference
Learn more and submit your research. Deadline: September 25, 2020, 11:59 PDT.

Southern Regional Meeting
Southern Regional Meeting
Learn more and submit your research. Deadline: October 9, 2020, 11:59 CST.

 
AFMR Publications Highlights

Journal of Investigative Medicine (JIM)

Journal of Investigative Medicine (JIM)

Podcasts

National Breast Feeding Month with Samrat Das
Guest: Samrat Das, MD, Associate Professor of Pediatrics, Duke University School of Medicine; pediatric hospitalist, Duke's Children
August 31, 2020

Review

Coronary and peripheral artery plaques: do differences in plaque characteristics translate to differences in lipid management?
Shirling Tsai, Gloria Lena Vega; 10.1136/jim-2019-001252

Original Research

Bupropion in the treatment of postural orthostatic tachycardia syndrome (POTS): a single-center experience
Rohit Vyas, Zeid Nesheiwat, Mohammed Ruzieh, Zaid Ammari, Mohammad Al-Sarie, Blair Grubb; 10.1136/jim-2020-001272

MiR-3150b-3p inhibits the proliferation and invasion of cervical cancer cells by targeting TNFRSF11a
Zhijuan Yu, Liguo Wang, Xiujuan Li; 10.1136/jim-2020-001284

Brief Reports

Use of capillary ketones monitoring in treatment of mild ketotic crisis in people with ketosis-prone atypical diabetes
Eugene Sobngwi, Christine Ghislaine G Ngo Ngai, Martine Etoa Etoga, Eric Lontchi-Yimagou, Armand Mbanya, Mesmin Dehayem, Jean-Claude Mbanya; 10.1136/jim-2019-001267

Analysis of count data in the setting of cervical cancer detection
Christina G Bracamontes, Thelma Carrillo, Jane Montealegre, Leonid Fradkin, Michele Follen, Zuber D Mulla; 10.1136/jim-2020-001381


Journal of Investigative Medicine High Impact Case Reports (JIM-HICR)

JIM — High Impact Case Reports

A Rare Presentation of Choledochoduodenal Fistula Due to Ovarian Cancer Metastasis
Choledochoduodenal fistula (CDF) is an abnormal communication between the common bile duct and the duodenum. It accounts for about 5% to 25% of the total biliary fistulas and is usually due to a perforated duodenal ulcer, choledocholithiasis, and complications secondary to tuberculosis or could be iatrogenic. Primary intrabilliary tumors usually cause obstructive jaundice and rarely biliary metastasis arising from other organs like colon, breast, and lungs can cause obstructive jaundice. There has been a case report of metastasis from ovarian cancer to the major papilla of the duodenum but no reported cases of it causing a CDF. We report a rare case of an 83-year-old female with ovarian cancer who developed a metastatic lesion to the duodenum eventually resulting in a CDF.

Collagenous Gastritis: An Unusual Presentation with Tubular Shaped Stomach
Collagenous gastritis is a rare histopathologic entity that causes marked subepithelial collagen deposition in the gastric mucosa. Clinical presentation is diverse, considering only less than 100 cases have been reported. However, we report a unique case of isolated collagenous gastritis in a 71-year-old female who presented with a 6-month history of dyspepsia and 27 kg weight loss. Her endoscopic findings revealed a tubular shaped stomach with diffuse gastric mucosal atrophy, findings that differ with previous case reports of a cobblestone pattern. Treatment remains unclear.

Capillary Leak Syndrome from Rituximab Therapy of Lymphoma
Capillary leak syndrome (CLS) is characterized by plasma extravasation into the interstitium with resultant hypotension, anasarca, hemoconcentration, and hypoalbuminemia in the absence of albuminuria. Initially reported in Clarkson’s disease (systemic capillary leak syndrome), CLS has been observed in multiple disease settings, the most common being sepsis. In oncology, CLS has been reported more often as a complication from therapy, and less often from malignancy. In this case study, we documented clinical manifestation, laboratory features, and radiological findings of CLS from rituximab therapy when employed in combination with a multi-agent chemotherapy regimen (EPOCH-R). Differentiating drug-induced CLS from sepsis, which presents with the same clinical features, is important in avoiding further exposure to rituximab, which could be fatal to the patient.

Spontaneous Tumor Lysis Syndrome in Blastoid-Variant Mantle Cell Lymphoma: Considerations for the General Internist
Spontaneous tumor lysis syndrome (SPTLS) is a rare phenomenon that can manifest in rapidly proliferating hematological malignancies and solid tumors prior to initiating cytotoxic therapy. We encountered a patient who originally presented with diffuse lymphadenopathy, abdominal distention, and dyspnea, who had laboratory abnormalities suggestive of SPTLS. His peripheral flow cytometry and lymph node biopsy revealed blastoid-variant mantle cell lymphoma. Prior to initiating chemotherapy, acute kidney injury (AKI) and uric acid had improved with intravenous fluids and the initiation of allopurinol. However, after beginning chemotherapy, the patient developed a second AKI concerning for tumor lysis syndrome (TLS). He went on to have renal recovery and did not require renal replacement therapy. With the exception of case reports, there is limited evidence to guide general medicine clinicians who encounter cases of SPTLS. Expert-based guidelines are available to guide use of rasburicase, an uricase enzyme, before initiation of chemotherapy for certain malignancies when risk for TLS is considered high. Despite these guidelines, the role of rasburicase in preventing AKI remains controversial after inconclusive results in a meta-analysis. The causative relationship between uric acid and AKI in TLS is based on a mechanism of tubular obstruction. There are also mechanisms by which uric acid may cause AKI without tubular obstruction related to acute hyperuricemic nephropathy. Further characterization of the role of uric acid in causing AKI in patients without tubular obstruction may identify new mechanisms of injury and offer insight into new treatment strategies.

 
NIH Grants & Funding: Coronavirus Disease 2019

NIH

The NIH Coronavirus Disease 2019 (COVID-19): Information for NIH Applicants and Recipients of NIH Fund page offers a wide range of guidance on research funding.

The Guidance portion includes the following sections:
  • Overview presentation (in PowerPoint and Word formats)
  • Proposal Submission & Award Management
  • Human Subjects & Clinical Trials
  • Animal Welfare
  • Peer Review
  • FAQs (last updated April 13, 2020)
In the Funding section, there are two sections:
  • Blog: COVID-19 Funding and Funding Opportunities
  • List of NIH Funding Opportunities Specific to COVID-19

Learn more.

 
Global Research on Coronavirus

World Health Organization (WHO)

The World Health Organization (WHO) has a dedicated page devoted to global research on coronavirus.

Elements include:

 
Johns Hopkins Coronavirus Research Center

News and information on COVID-19 is constantly changing.

Johns Hopkins has updated and expanded its resource center.

The website now has separate pages covering:

Its Interactive Map is updated throughout the day.
COVID-19 Interactive Map

 
AFMR 2021 Meeting Dates Set

Dates have been set for AFMR Regional and Affiliate meetings for 2021. Meeting dates, locations, and abstract information are listed below based on date.

Visit the AFMR website to get the latest updates on 2021 AFMR Meetings & Events.
Cherry Wongtrakool, MD, VP of Meetings & Programs
Cherry Wongtrakool, MD
VP of Meetings & Programs

January 2021
Western Regional Meeting
Western Regional Meeting
January 29-30, 2021
Going Virtual for 2021

Abstract Submission Now Open
Submit Abstract
Deadline: Friday, September 25 at 11:59 PM PDT

Abstracts will continue to be published in the Journal of Investigative Medicine.
February 2021
Southern Regional Meeting
Southern Regional Meeting
February 25-27, 2021
Going Virtual for 2021

SRM Abstract Submission Opening mid-August
Submit Abstract
Note: This link will not work until submissions open.
Deadline: October 9 at 12:00 midnight EST

Abstracts will continue to be published in the Journal of Investigative Medicine.
March 2021
Translational Science 2021
Translational Science 2021
March 30, 2021-April 2, 2021
Washington, DC
April 2021
Eastern Regional Meeting
Eastern Regional Meeting
April 2, 2021
Marriott Wardman Park, Washington, DC
Abstract Deadline (Tentative): December 1, 2020
Midwest Clinical & Translational Research Meeting
Midwest Clinical & Translational Research Meeting
April 8-9, 2021
Holiday Inn Mart Plaza, Chicago, Illinois
Abstract Deadline: January 10, 2021
May 2021
Experimental Biology 2021
May 1-4, 2021
Indianapolis, IN