Volume I, Issue 10: November 2020
American Federation for Medical Research (AFMR) Insights
AFMR Website Meetings/Events Calendar Submit a JIM manuscript Follow AFMR on Twitter
IN THIS ISSUE

 

Janice P. Dutcher, MD, AFMR President
Janice P. Dutcher, MD
AFMR President
AFMR's mission is to develop and mentor tomorrow’s leaders in medical research. The organization achieves this goal by:

2021 AFMR National Awards
One way that AFMR fosters excellence in training and successful development of medical investigators is through its national awards — the Outstanding Investigator and the Junior Physician-Investigator Awards. More

 

Virtual Symposia

This month, the society is launching the AFMR Endowment Fund.

The initiative has been created to underwrite AFMR’s national awards:

In addition, it will support the Henry Christian Awards — named after AFMR's founder. These honors recognize outstanding abstracts submitted to AFMR regional meetings.

Now, more than ever, AFMR needs to support young scientists — giving them a foundation for future careers in medical research. More

 
Updates on COVID Therapeutics/Vaccine Research

COVID-19 Researchers around the world are racing to develop therapeutics and vaccines aimed at stemming the coronavirus pandemic.

Some updates:

Therapeutics

Vaccines

 
AFMR Virtual Symposia Now Available in the Virtual Education Series Archive

You can still take advantage of AFMR Virtual Education Series offerings.

Recordings of this fall's events have been posted in the Virtual Symposia Archive.

Presentations available include:

Check them out today. Register to create a log-on and password that will permit you to view these and future presentations. All offerings are free to members and nonmembers.

 
Submit Your Research to the Eastern & Midwestern Regional Meetings

Submit your abstracts to the 2021 AFMR Eastern Regional Meeting and Midwest Clinical & Translational Research Meeting.

Everyone is eligible to submit abstracts to these two events, which will be virtual due to uncertainties of the COVID 19 pandemic. Join AFMR to be eligible for awards.

Eastern Regional Meeting
Eastern Regional Meeting
Deadline: Tuesday, December 1, 2020, 11:59 Eastern
Learn more and submit your research.

Midwestern Regional Meeting
Midwest Clinical & Translational Research Meeting
Deadline: Sunday, January 10, 2021, 11:59 CST
Learn more and submit your research.

 

American Federation for Medical Research

Application submissions are open for AFMR’s two national awards:

Both awards are open to current AFMR members. Check to determine the status of your AFMR membership.

Awards are usually presented in-person at the Translational Science Meeting in Washington, DC.

In 2021, the honors will be bestowed during a virtual awards ceremony during which the winners will present their research. More

 
Join the AFMR Conversation: Connect on Twitter & LinkedIn

AFMR Research

AFMR Research
Journal of Investigative Medicine

Journal of Investigative Medicine

On LinkedIn

American Federation for Medical Research

American Federation for Medical Research

 
Advocacy Update: FASEB Endorses Legislation Supporting Researchers Impacted by COVID-19 Pandemic

Federation of American Societies for Experimental Biology (FASEB) FASEB has endorsed two bills in Congress aimed at supporting researchers affected by the COVID19 pandemic:

Learn more.

 
AFMR Publications Highlights

Journal of Investigative Medicine (JIM)

Journal of Investigative Medicine (JIM)

Podcast
National Atrial Fibrillation Month with Richard Lange
Guest: Richard Lange, MD, President, Texas Tech Health Sciences Center, El Paso
October 1, 2020

Review
Advanced clinical trials of dentric cell vaccines in ovarian cancer Editor's Choice
Quan Guo, Qing Yang, Jun Li, Guipeng Liu, Igor Nikoulin, Steve Jia
10.1136/jim-2020-001355

Original Research
Association between acute respiratory failure requiring mechanical ventilation and the production of advanced glycation end products
Hawa Edriss, Adebayo J Molehin, Rocio Gavidia, Kavitha Selvan, Kenneth Nugent
10.1136/jim-2020-001419

Clopidogrel can be an effective complementary prophylactic for drug-refractory migraine with patent foramen ovale
Yichen Guo, Yujie Shi, Dan Zhu, Rui Liu, Yi Qi, Guogang Luo
10.1136/jim-2020-001342

Effect of ischemic postconditioning on cell apoptosis and expression of relevant genes in non-culprit coronary arteries
Jian Wang, Song-Yuan He
10.1136/jim-2020-001328

Brief Report
'Omics' approaches for studying the microbiome in Alopecia areata
Daniela Pinto, Anna Trink, Elisabetta Sorbellini, Giammaria Giuliani, Fabio Rinaldi
10.1136/jim-2020-001426

Letter to the Editor
Frailty assessment in the COVID-19 pandemic
Kenneth Jordan Ng Cheong Chung, Vijay Kunadian
10.1136/jim-2020-001540

Response: Frailty assessment in the COVID-19 pandemic
Christian Labenz, Jörn M Schattenberg, Marcus-Alexander Wörns, Martin F Sprinzl
10.1136/jim-2020-001556


Journal of Investigative Medicine High Impact Case Reports (JIM-HICR)

JIM — High Impact Case Reports

Subacute Aspergillosis "Fungal Balls" Complicating COVID-19
Severe acute respiratory syndrome coronavirus-2 infection (SARS-CoV-2), commonly known as COVID-19 (coronavirus disease-2019), began in the Wuhan District of Hubei Province, China. It is regarded as one of the worst pandemics, which has consumed both human lives and the world economy. COVID-19 infection mainly affects the lungs triggering severe hypoxemic respiratory failure, also providing a nidus for superimposed bacterial and fungal infections. We report the case of a 73-year-old male who presented with progressive dyspnea; diagnosed with SARS-CoV-2–related severe acute respiratory distress syndrome and complicated with lung cavitations growing Aspergillus sp. COVID-19, to our knowledge, has rarely been associated with subacute invasive pulmonary aspergillosis with aspergillomas. Subacute invasive pulmonary aspergillosis as a superimposed infection in patients with SARS-CoV-2 is a rare entity. By reporting this case, we would like to make the readers aware of this association.

Atezolizumab-Induced Bell’s Palsy in a Patient with Small Cell Lung Cancer
Immune checkpoint inhibitors are rapidly becoming popular therapeutic options for patients suffering from a number of malignancies. Atezolizumab is a programmed cell death ligand-1 inhibitor, and binding to this ligand decreases the ability of tumor cells to evade the immune system, resulting in self-tolerance. While inhibition of these molecules leads to increased T-cell destruction of tumor cells, it also may lead to autoimmune destruction of healthy cells. Neurotoxicity is a rare complication of immune checkpoint inhibitor therapy, and facial palsy as a complication of atezolizumab therapy has only been reported in one additional study. We present the case of a 68-year-old female with a history of small cell carcinoma of the lung presenting with sudden-onset facial palsy and numbness of the distal extremities in the setting of receiving atezolizumab immunotherapy. Our patient was managed with temporary cessation of her immunotherapy, oral prednisone, and supportive measures. Within 4 weeks, the patient had complete resolution of her facial palsy and was able to resume immunotherapy without further complication. Clinicians should be aware of this rare adverse effect in order to enact early management including temporary cessation of therapy to prevent morbidity in patients undergoing immunotherapy.

Massive Upper Gastrointestinal Bleeding Following LAMS (Lumen-Apposing Metal Stent) Placement
Pancreatic pseudocyst is a common complication of pancreatitis. Pseudocysts may require decompression when they become painful, infected, or start compressing surrounding organs. Decompression is achieved by endoscopic cystogastrostomy. Recently, the use of lumen-apposing metal stent (LAMS) for cystogastrostomy has gained popularity due to ease of use and high technical success. LAMS has a wider lumen, which allows for direct endoscopic necrosectomy in the cases of walled-off necrosis. Our patient is a 30-year-old male who presented with massive hematemesis and dizziness. He had a history of chronic alcohol-induced pancreatitis. Three weeks before the presentation, he underwent a cystogastrostomy with LAMS placement to treat a 10-cm walled-off necrosis. Urgent computed tomography (CT) scan did not reveal any acute finding suggestive of bleeding. Esophagogastroduodenoscopy showed blood protruding from the LAMS with a large clot formation. Attempts to stop bleeding were unsuccessful. He underwent CT angiography of the abdomen. CT angiography showed a bleeding pseudoaneurysm (PA) believed to be a complication of the LAMS. Subsequently, multiple coils were placed in the splenic artery near the PA. The patient continued to improve without a further drop in hemoglobin and was eventually discharged. PA formation and subsequent rupture is a rare delayed complication of LAMS. It may lead to massive gastrointestinal bleeding with a high mortality rate. Diagnostic delays have resulted in increased mortality by 60%. In this article, we present a case of massive gastrointestinal bleeding due to a ruptured splenic artery PA presenting as a delayed complication of LAMS.

 
NIH Grants & Funding: Coronavirus Disease 2019

NIH

The NIH Coronavirus Disease 2019 (COVID-19): Information for NIH Applicants and Recipients of NIH Fund page offers a wide range of guidance on research funding.

The Guidance portion includes the following sections:
  • Overview presentation (in PowerPoint and Word formats)
  • Proposal Submission & Award Management
  • Human Subjects & Clinical Trials
  • Animal Welfare
  • Peer Review
  • FAQs (last updated April 13, 2020)
In the Funding section, there are two sections:
  • Blog: COVID-19 Funding and Funding Opportunities
  • List of NIH Funding Opportunities Specific to COVID-19

Learn more.

 
Global Research on Coronavirus

World Health Organization (WHO)

The World Health Organization (WHO) has a dedicated page devoted to global research on coronavirus.

Elements include:

 
Johns Hopkins Coronavirus Research Center

News and information on COVID-19 is constantly changing.

Johns Hopkins has updated and expanded its resource center.

The website now has separate pages covering:

Its Interactive Map is updated throughout the day.
COVID-19 Interactive Map

 
AFMR 2021 Meeting Dates Set

Dates have been set for AFMR Regional and Affiliate meetings for 2021. Meeting dates, locations, and abstract information are listed below based on date.

Visit the AFMR website to get the latest updates on 2021 AFMR Meetings & Events.
Cherry Wongtrakool, MD, VP of Meetings & Programs
Cherry Wongtrakool, MD
VP of Meetings & Programs

January 2021
Western Regional Meeting
Western Regional Meeting
January 29-30, 2021
Going Virtual for 2021
February 2021
Southern Regional Meeting
Southern Regional Meeting
February 25-27, 2021
Going Virtual for 2021
March 2021
Translational Science 2021
Translational Science 2021
March 30, 2021-April 2, 2021
Washington, DC
April 2021
Eastern Regional Meeting
Eastern Regional Meeting
April 2, 2021
Marriott Wardman Park, Washington, DC
Abstract Deadline (Tentative): December 1, 2020
Midwest Clinical & Translational Research Meeting
Midwest Clinical & Translational Research Meeting
April 8-9, 2021
Holiday Inn Mart Plaza, Chicago, Illinois
Abstract Deadline: January 10, 2021
May 2021
Experimental Biology 2021
May 1-4, 2021
Indianapolis, IN