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AFMR Foundation

2010 Eastern Regional Meeting
April 5-6, 2010
The Marriott Washington Wardman Park Hotel
Washington, DC

AFMR Eastern Program
MONDAY, APRIL 5, 2010
11:00 AM EASTERN MEETING REGISTRATION
12:15 PM - 12:30 PM AFMR INTRODUCTION AND WELCOME
Robert J. Freishtat, MD, MPH
AFMR Secretary/Treasurer and Eastern AFMR Chair
12:30 PM - 1:30 PM 1st ANNUAL FORMER AFMR/AFCR PRESIDENT’S ADDRESS
Sustainability: Ensuring the Future of Clinical Research

Charles W. Flexner, MD
Professor of Medicine, Pharmacology and Molecular Sciences, and International Health; Deputy Director, Institute of Clinical and Translational Research, Johns Hopkins University
AFMR President 2000 – 2001


Dr. Flexner's address draws from his many titles and responsibilities within the medical research field to evaluate current threats to clinical and translational research and discuss some of the most promising paths moving forward for the discipline.
1:30 PM - 2:45 PM SCIENTIFIC SESSION I
Oral Presentations (10 minute presentation with 5 minute Q&A)
Moderators: Leticia Ryan, MD and Christa Zerbe, MD
*1. A REDUCTION IN EJECTION FRACTION DURING STRESS WITHIN THE NORMAL RANGE WITH GATED SPECT IMAGING IS NOT ASSOCIATED WITH INCREASED MORTALITY
I. Opoku-Asare1,2, B. Curry1, B. Shamloo2, J. Morrissette2, K. O'Regan2, E. Goheen2, G. Trachiotis3, P. Kokkinos2, M. Greenberg1,2
1Cardiology, Howard University Hospital, Washington, DC, 2Cardiology, Washington DC VA Medical Center, Washington, DC, 3Cardiothoracic Surgery, Washington DC VA Medical Center, Washington, DC
2. VITAMIN D DEFICIENCY AS A RISK FACTOR FOR ALLERGY IN THE US USING THE NHANES SURVEY
A. Valluri, M. Frieri
Medicine, Nassau University Medical Center, East Meadow, NY
3. SECOND HARMONIC GENERATION AND ITS CLINICAL UTILIZATION IN LIVER FIBROSIS
M. Tadros1, J. Birk1, P. Campognola2, N. Oleg2, F. Forouhar3
1Medicine, Gastroenterology Division, UCONN, Hartford, CT, 2UCONN, Dept. of Cell Analysis and Modeling, Hartford, CT, 3Department of Pathology, UCONN Health Center, Hartford, CT
4. A COMPARISON OF KIDNEY DYSFUNCTION AND HYPERTENSION IN ALLOGENEIC AND AUTOLOGOUS HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS
J.M. Belcher1, P. McSweeney2,U. Iyanam1, C. Parikh1
1Internal Medicine, Yale University, West Haven, CT 2 Rocky Mountain Cancer Center, Denver, CO
5. RELATIONSHIP BETWEEN LEFT VENTRICULAR MASS AND AORTIC VALVE CALCIFICATION: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS
S. Elmariah1, K.D O'Brien2, M.J. Budoff3, D. Bluemke4,5, J.A. Delaney2 ,V. Fuster1, R.A. Kronmal2, J.L. Halperin1
1Cardiovascular Institute, The Mount Sinai School of Medicine, New York, NY, 2University of Washington, Seattle, WA, 3Harbour-UCLA Medical Center, Torrance, CA, 4Johns Hopkins University School of Medicine, Baltimore, MD, 5National Institutes of Health, Bethesda, MD, 6Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
2:45 PM - 3:00 PM BREAK
3:00 PM - 4:15 PM SCIENTIFIC SESSION II
Oral Presentations (10 minute presentation with 5 minute Q&A)
Moderators: Ravikumar Balasubramanian, MD, PhD and Sabah Iqbal, MD
*6. A PROSPECTIVE STUDY AND COST ANALYSIS OF MALARIA TESTING AND EMPIRIC TREATMENT
R. Parikh1,2, M. Tarpley1,2, I. Amole2, M. Davidson1, S. Vermund1, D. Gbadero
1Vanderbilt University School of Medicine, Nashville, TN, 2Baptist Medical Centre Ogbomoso (Bowen University Teaching Hospital), Ogbomoso, Oyo, Nigeria
*7. OVERCOMING HETEROGENEITY IN PEDIATRIC ASTHMA: TOBACCO SMOKE AND ASTHMA CHARACTERISTICS WITHIN PHENOTYPIC CLUSTERS
A.S. Benton1, Z. Wang1,2, J. Lerner1, M. Foerster1, S.J. Teach1,2, R.J. Freishtat1,2
1Children's National Medical Center, Washington, DC, 2George Washington University School of Medicine and Health Sciences, Washington, DC
8. PRIMARY CARE FOLLOW-UP AFTER EMERGENCY DEPARTMENT VISITS FOR LOWER RESPIRATORY ILLNESSES AMONG A DISADVANTAGED URBAN PEDIATRIC POPULATION
D.B. Liberman1, D.M. Quint2, R.J. McCarter2, S.J. Teach1,2
1Emergency Medicine, Children's National Medical Center, Washington, DC, 2Center for Clinical and Community Research, Children's National Medical Center, Washington, DC
*9. A RETROSPECTIVE STUDY TO EVALUATE THE IMPACT OF ERYTHROPOIETIN STIMULATING AGENTS ON CARDIOVASCULAR OUTCOMES INDEPENDENT OF THEIR EFFECT ON HEMOGLOBIN
C. Gandotra1, N. Koduri1, S. Loughlin2, M. Michael1, M.G. Daniel3, P. Sealy4, J. Diggs1, T. Mehta2
1Division of Cardiology, Howard University Hospital, Washington DC, 2Department of Nephrology, Washington Hospital Center, Washington, DC 3Center for Minority Health Services Research, Howard University, Washington, DC, 4Department of Internal Medicine, Howard University Hospital, Washington, DC
*HC 10. BISPHOSPHONATE USE AND THE PREVALENCE OF CARDIOVASCULAR CALCIFICATION IN WOMEN: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS
S. Elmariah1, J.A. Delaney2, K.D. O'Brien2, M.J. Budoff3, J. Vogel-Claussen4, V. Fuster1,5, R.A. Kronmal2, J.L. Halperin1
1Cardiovascular Institute, The Mount Sinai School of Medicine, New York, NY, 2University of Washington, Seattle, WA, 3Harbour-UCLA Medical Center, Torrance, CA, 4Johns Hopkins University School of Medicine, Baltimore, MD, 5Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
4:30 PM - 6:00 PM POSTER COMPETITION AND RECEPTION
In 2010, the Eastern Region will host a Poster Competition for those authors showcasing their posters at the Eastern Regional Meeting. All poster authors should be available at their poster during the Reception as assigned judges will be circulating and evaluating your work. Awards for the best Clinical Research and Basic Science Posters will be announced on Tuesday, April 6, 2010. Awards include a certificate, one (1) year free Associate membership in the AFMR and a one (1) year complimentary subscription to the AFMR's Journal of Investigative Medicine (JIM).
6:00 PM - 9:00 PM AFMR EASTERN SCHOLARS DINNER*
Featured speaker: Michael McPhaul, MD
Professor, UT Southwestern Medical Center
Editor–in-Chief, Journal of Investigative Medicine (JIM)
Stone's Throw Restaurant: Mica, Slate, Granite Rooms
*Invitation Only
TUESDAY, APRIL 6, 2010
7:00 AM EASTERN MEETING REGISTRATION
7:30 AM - 8:30 AM BREAKFAST WORKSHOP:
DEALING WITH CONFLICT AND NEGOTIATING:
SCIENCE VS. ART

Randal S. Weber, MD
Chair, Dept of Head and Neck Surgery
University of Texas MD Anderson Cancer Center
(Continental Breakfast Will Be Served)

Dr. Randal Weber will utilize his hands-on experience in the medical field and active involvement training young physician-scientists to discuss practical approaches required in the medical profession. This workshop will provide strategies for negotiating and resolving conflicts along with other pertinent topics to career development in medical research. Dr. Weber is a prolific author and lecturer both nationally and internationally and is bringing his expertise to the 2010 Eastern Regional Meeting.
8:30 AM - 10:00 AM RESEARCH ADVOCACY WORKSHOP
RESEARCH!AMERICA

Karen. A. Goraleski
Research!America, Vice President, Public Health Partnerships

Research!America will provide a 90-minute workshop focused on redirecting the communication style that is the coin of the realm in the academic research community and yet is a significant obstacle when attempting to communicate clearly with policymakers, the media and the public on the value of research. This workshop will specifically address why scientists must be a voice for research; clear language vs. jargon; broad brush strategies that can be used to convey the value of research to non-science audiences and will include an interactive portion. The goal of Resarch!America and their workshops is to help researchers (especially young investigators) better convey the value of what they do and to strengthen the collective voice of the science community through advocacy efforts for increased funding for research.
10:00 PM - 10:15 PM BREAK
10:15 AM - 11:00 AM BUILDING YOUR CAREER: GETTING PUBLISHED IN HIGH QUALITY BIOMEDICAL JOURNALS
Allison B. Reiss, M.D.
Head, Inflammation Section
Vascular Biology Institute
Winthrop University Hospital

Allison Reiss, MD, will offer a session based on her years of successful publication in biomedical journals. Being published in top journals is a great career builder and increases one's exposure to new professional opportunities. Dr. Reiss's talk will be comprised of important strategies and expert advice for becoming published and advancing careers in the clinical research profession.
11:00 AM - 12:15 PM AFMR PRESIDENTIAL PLENARY (SCIENTIFIC SESSION III)
Oral Presentations (10 minute presentation with 5 minute Q&A)
Moderator: Abdullah Salahudeen, MD, President, AFMR and Francis Miller, MD
*11. PROGNOSTIC SIGNIFICANCE OF CARBOHYDRATE ANTIGEN 125 IN PATIENTS WITH HEART FAILURE AND PRESERVED EJECTION FRACTION
S. Napan1, T. Aussawapokee2, E. Nargileci2, A. Qureshi2, S. Khadra2
1 Howard University, Washington, DC, 2 John H. Stroger, Jr. Hospital of Cook County, Chicago, IL
*HC 12. MECHANISMS OF PLATELET GRANZYME B INDUCED END-ORGAN APOPTOSIS IN SEPSIS
M. Sharron1,2, A.A. Wiles2, A.S. Benton2, R.J. Freishtat1,2
1Children's National Medical Center, Washington, DC, 2George Washington University School of Medicine, Washington, DC
*13. RELATIVE PRO-ATHEROGENIC IMPACT OF OMALIZUMAB VERSUS CELECOXIB ON CHOLESTEROL TRANSPORT PROTEINS IN THP-1 HUMAN MONOCYTES
B.V. Kim, I. Voloshyna, M. Littlefield, L. Fonacier, A.B. Reiss
Rheumatology, Allergy & Immunology, Winthrop University Hospital, Mineola, NY
14. ASTHMATIC BRONCHIAL EPITHELIUM IS INTRINSICALLY INFLAMMOGENIC, MITOTICALLY DYSSYNCHRONOUS, AND IS RESCUED BY GLUCOCORTICOIDS
R.J. Freishtat1,2, A.M. Watson1, A.S. Benton1, S.F. Iqbal1,2, D.K. Pillai1, M.C. Rose1, E.P. Hoffman1
1 Department of Integrative Systems Biology, Children's National Medical Center, Washington, DC 2 Division of Emergency Medicine, Children's National Medical Center, Washington, DC
*15. RESVERATROL EXHIBITS ANTI-ATHEROGENIC PROPERTIES BY FACILITATING CHOLESTEROL EFFLUX FROM THP-1 HUMAN MONOCYTES/MACROPHAGES
O. Hai, K. Anwar, P.A. Wirkowski, I. Voloshyna, S. Carsons, A.B. Reiss
Medicine, Winthrop University Hospital, Mineola, NY
12:15 PM - 12:30 PM Announcement of Poster Competition Awards
12:30 PM Adjourn

*indicates 2010 Eastern Scholar Award recipient
*HC indicates Henry Christian Award recipient
*JPI indicates Junior Physician Investigator Award recipient

Posters
P1. PRIMARY HYPERPARATHYROIDISM: A POTENTIALY TREATABLE MEDICAL CAUSE OF PROGRESSION OF AORTIC STENOSIS. A CASE REPORT.
R. Muppidi, S. Duggal, J. Aujla, N. Iqbal, S. Nisar
Cardiothoracic Surgery, Cleveland Clinic Foundation, Cleveland, OH
P2. THE INFLUENCE OF CULTURE AND GENETICS IN THE EXPRESSION OF THE METABOLIC SYNDROME
P.I. Altieri, Y. Figueroa, H.L. Banchs, N. Escobales, C. Maria
Medicine and Physiology, University of Puerto Rico, Puerto Rico
P3. PREVENTION OF IN HOSPITAL SUDDEN CARDIAC DEATH WITH THE USE OF AUTOMATED EXTERNAL DEFIBRILLATORS IN HIGH RISK PATIENTS
V. Vaynshteyn, O. Burzyantseva, S. Jayawardena, J. Hoo, S. Siegel
Medicine, Coney Island Hospital, Brooklyn, NY
P4. HIGH CUMULATIVE RADIATION DOSE OF PATIENTS UNDERGOING NUCLEAR MYOCARDIAL PERFUSION IMAGING
A.J. Einstein, A. Bernheim, M. Kulon, S. Balter
Columbia University, New York, NY
P5. P-GLYCOPROTEIN DOES NOT CONTRIBUTE TO GLUCOCORTICOID EFFLUX IN A RESPIRATORY EPITHELIAL CELL MODEL
J. Cohen1, A.S. Benton2, F. Nwachukwu3, T. Ozedirne4, R.J. Freishtat1,2
1Children's National Medical Center, Washington, DC, 2Children's Research Institute, Washington, DC, 3Temple University, Philadelphia, PA, 4University of California-Davis, Davis, CA
P6. NEWBORNS IN THE EMERGENCY DEPARTMENT: WHAT'S THE HARM?
S.F. Iqbal1,2, T. Ozedirne2, R.J. Freishtat1,2, J.M. Chamberlain1
1Division of Emergency Medicine, Children's National Medical Center, Washington, DC, 2Department of Integrative Systems Biology, Children's National Medical Center, Washington, DC
P7. RELATIONSHIP BETWEEN FRAMINGHAM RISK SCORE AND METABOLIC SYNDROME FOR PREDICTING CORONARY ARTERY DISEASE
J. Lander, N. Coplan, D. Hersh, S. Ayyanathan, G. Panagaopoulos, H. Levitt, S. Toor, M. Jimenez, R. Schaller, S. Patel
Cardiology, Lenox Hill Hospital, New York, NY
P8. PEDIATRIC RESIDENT KNOWLEDGE AND COMFORT LEVEL WITH RESUSCITATION FOLLOWING AN EDUCATIONAL INTERVENTION
M. Lorch, D. Agrawal, K. O'Connell
Emergency Medicine, Children's National Medical Center, Washington, DC
P9. PATHOLOGY OF SOME OBSTETRIC-PEDIATRIC INTERVENTIONS
D.R. Shanklin1,2
1 Marine Biological Laboratory, Woods Hole, MA, 2Pathology/Lab Medicine, University of Tennessee, Memphis, TN
P10. LONG-TERM EFFECTS OF A MOCK CODE CURRICULUM ON PEDIATRIC RESIDENT EDUCATION
A. Troy1, K. O'Connell3, D. Friedman2, P. Zaveri3
1Pediatrics, Children's National Medical Center, Washington, DC, 2Cardiology, Children's Hospital of Los Angeles, Los Angeles, CA, 3Emergency Medicine, Children's National Medical Center, Washington, DC
P11. CARDIAC MRI ANALYSIS OF RIGHT VENTRICULAR FUNCTION IN VALVULAR HEART DISEASE
A. Nasur1,2, R. Chintala1, M. Greenberg1,2, G. Trachiotis2
1Cardiology, Howard University Hospital, Washington, DC, 2VA Medical Center, Washington, DC
P12. EPIDEMIOLOGY OF PEDIATRIC FOREARM FRACTURES IN WASHINGTON DC, 2003-2006
L. Ryan, J.L. Wright, K. Searcy, S. Singer, R. Wood
J. Chamberlain, Children's National Medical Center, Washington, DC
P13. PATIENT CHARACTERISTICS ARE ASSOCIATED WITH ED OUTCOMES FOR CHILDREN
M.C. Levine1, X. Zeng2, E. Bish2, R. Xie2, A.D. Slonim3
1Emergency Medicine, Children's National Medical Center, Washington, DC, 2Grado Department of Industrial Engineering, Virginia Polytechnic Institute, Blacksburg, VA, 3Virginia Tech-Carilion School of Medicine, Carilion Medical Center, Roanoke, VA
P14. HEMOLYTIC AND THROMBOGENIC CHARACTERISTICS OF ECMO SYSTEMS AT SIMULATED FLOW RATE FOR NEONATES
A.D. Meyer1, A.A. Wiles1, O. Rivera1, E.C. Wong1, R.J. Freishtat1, K. Rais-Bahrami1, H.J. Dalton2
1Children's National Medical Center, Washington, DC, 2Phoenix Children's Hospital, Phoenix, AZ
P15. AIRWAY PLATELET ACTIVATION IS ASSOCIATED WITH AIRWAY EOSINOPHILIC INFLAMMATION IN ASTHMA
A.S. Benton1, N. Kumar2, J. Lerner1, A. Wiles1, M. Foerster1, S.J. Teach3,4,5, R.J. Freishtat1,4,5
1Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC, 2George Washington University School of Medicine and Health Sciences, Washington, DC, 3Center for Clinical and Community Research, Children's National Medical Center, Washington, DC, 4Division of Emergency Medicine, Children's National Medical Center, Washington, DC, 5Department of Pediatrics, George Washington University School of Medicine and Health Sciences , Washington, DC
P16. DOPAMINE DEGRADATION BY HYPOCHLOROUS ACID: IMPLICATIONS FOR PARKINSONISM
S.K. Sinha, T.M. Jeitner
Winthrop University Hospital, Mineola, NY
P17. CORONARY ARTERITIS IN WEGENER'S GRANULOMATOSIS
N.Y. Win, K. Dasari, A. Sahni, A. Khanna
Medicine, Coney Island Hospital, Brooklyn, NY
P18. A COMPARATIVE STUDY BETWEEN 18 ELECTROCARDIOGRAPHIC CRITERIA FOR PREDICTION OF LEFT VENTRICULAR HYPERTROPHY IN CAUCASIANS AND AFRICAN AMERICANS USING CARDIAC MRI
B.K. Shamloo1,2, R.S. Chintala1, A. Onuora1,2, G.D. Trachiotis2, P. Kokkinos2, M.D. Greengerg1,2
1Howard University Hospital, Rockville, MD, 2Cardiology, Washington DC Veterans Medical Affair, Washington, DC
P19. MACROLIDE REPRESSION OF MUC5AC GENE EXPRESSION IN HUMAN LUNG EPITHELIAL CELLS
R. Yim1, Y. Chen2, M. Smith2, M.C. Rose2
1Division of Pulmonary Medicine, Children's National Medical Center, Washington, DC, 2Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC
P20. ASSOCIATIONS BETWEEN GENETIC VARIANTS IN VITAMIN D METABOLISM AND ASTHMA PHENOTYPE TRAITS IN YOUNG AFRICAN AMERICANS
D. Pillai1,2, S.F. Iqbal1,2, A.S. Benton1,2, T. Ozerdirne3, H. Holbrook1, S.J. Teach2, R.J. Freishtat1,2
1Department of Integrative Systems Biology, Children's National Medical Center, Washington, DC, 2School of Medicine and Health Sciences, George Washington University, Washington, DC, 3University of California at Davis, Davis, CA
P21. SPONTANEOUS CORONARY ARTERY DISSECTION: AGGRESSIVE OR CONSERVATIVE MANAGEMENT?
R.S. Chintala1, S. Behrooz1, A. Nasur2, M. Ghazvini2, R. Chakilam1, S. Chalasani1, J. Diggs2, S. Singh2,3
1Internal Medicine, Howard University Hospital, Washington, DC, 2Cardiology, Howard University Hospital, Washington, DC, 3Cardiology, Veteran Affairs Medical Centre, Washington, DC
P22. HEPATOCELLULAR CARCINOMA IN A NON CIRRHOTIC PATIENT WITH PRIMARY HEMOCHROMATOSIS WITHOUT EVIDENCE OF IRON OVERLOAD
P. Singh1, R. Lerner1, H. Kaur2,S. M. Rafiyuth1,G. S. Lamba1,R. Patel3
1Hematology And Oncology, Westchester Medical Center, Valhalla, NY, 2Internal Medicine, Westchester Medical Center, Valhalla, NY, 3Department Of Pathology, Westchester Medical Center, Valhalla, NY

*indicates 2010 Eastern Scholar Award recipient
*HC indicates Henry Christian Award recipient
*JPI indicates Junior Physician Investigator Award recipient

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