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AFMR 2016 Eastern Regional Meeting

Accreditation


Learning Objectives
This activity is designed for those involved in biomedical and patient-oriented clinical, translational and laboratory research. Upon completion of this course, participants will be able to:
  • Examine and evaluate current information pertaining to health, patient care, research discoveries, clinical guidelines that may be applied to practice
  • Critically evaluate the basic discoveries and the translational process
  • Identify research methods and practices used by different disciplines to be applied to one's individual practice
  • Present, discuss, and defend original research through respective interactions with peers and mentors
  • Identify tools and resources to be used for medical research funding advocacy on behalf of the medical and research communities
  • Create relationships and interact with the medical research community

Program and Abstracts | Posters


WEDNESDAY, APRIL 13, 2016
Hampton Room
6:30 AM - 7:30 AM
EASTERN MEETING REGISTRATION & CONTINENTAL BREAKFAST
7:00 AM - 8:00 AM
BREAKFAST WORKSHOP
Relating Mechanisms of Immune Development and Immunological Tolerance to Immune Checkpoint Inhibition in Cancer Treatments
Chairperson: Iuliana Shapira, MD
SUNY Downstate, Brooklyn NY
Speakers: Susan Gottesman, MD, PhD
Christopher Roman, PhD
SUNY Downstate, Brooklyn NY
Clinical Expert: Janice Dutcher, MD
Cancer Research Foundation, Bronx NY
Moderator: Peter Wiernik, MD
Cancer Research Foundation, Bronx NY
8:15 AM - 8:30 AM
AFMR INTRODUCTION AND WELCOME
Iuliana Shapira, MD
SUNY Downstate, Brooklyn NY
Chair, AFMR Eastern Region
8:30 AM - 10:30 AM
SCIENTIFIC SESSION I
Moderators: Hooman Mirzakhani, MD, PhD
Brigham and Women's Hospital/HMS, Boston MA

Shireen Atabaki, MD
Children's National Medical Center, Washington DC
1.
Comparative Effect of Selective and Non-Selective Cox-2 Inhibitors on Lipid Accumulation in Human Macrophages
Lora J. Kasselman1,3, Iryna Voloshyna1,3, Michael J. Littlefield1,3, Nicolle Siegart1,3, Steven E. Carsons1,2, Irving Gomolin1, Joshua De Leon1,3, Allison B. Reiss1,3
1Department of Medicine, Winthrop University Hospital, Mineola, NY, United States, 2Rheumatology and Allergy, Winthrop University Hospital, Mineola, NY, United States, 3Winthrop Research Institute, Winthrop University Hospital, Mineola, NY, United States
2.
Higher Vitamin D Levels in Early Pregnancy Are Associated with Reduced Risk of Preeclampsia - Observational, Mechanistic, and Experimental Evidence from the VDAART Trial
Hooman Mirzakhani1, 3, 14, Augusto A. Litonjua1, 2, 3, 14, Thomas McElrath3, 4, George O'Connor5, Aviva Lee-Paritz6, Ronald Iverson6, George Macones7, Robert Strunk8, Leonard B. Bacharier8, Robert Zeiger9, Bruce W. Hollis10, Diane E. Handy11, Amitabh Sharma1, 3, 14, Nancy Laranjo1, 14, Benjamin Harshfield1, 14, Vincent Carey1, 3, 14, Weiliang Qiu1, 3, 14, Marc Santolini1, 12, Shikang Liu12, Divya Chhabra13, Daniel A. Enquobahrie15, Michelle A. Williams16, Joseph Localzo3, 14, Scott T. Weiss1, 3, 14, 17
1Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States 3Harvard Medical School, Boston, MA, United States 4Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, United States 5Pulmonary Center, Department of Medicine, Boston Medical Center, Boston University, Boston, MA, United States 6Department of Obstetrics and Gynecology, Boston Medical Center, Boston University, Boston, MA, United States 7Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University, St. Louis, MO, United States 8Division of Pediatric Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University, St. Louis, MO, United States 9Department of Allergy and Research and Evaluation, Kaiser Permanente Southern California Region, San Diego and Pasadena, CA, United States 10Department of Pediatrics, Medical College of South Carolina, Charleston, SC, United States 11Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States 12Center for Interdisciplinary Research on Complex Systems, Department of Physics, Northeastern University, Boston, MA, United States 13Division of Pediatric Pulmonary, Department of Pediatrics, University of California, San Diego, CA, United States 14Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States 15Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, United States 16Department of Epidemiology, Department of Global Health and Populations, Harvard School of Public Health, Boston, MA, United States 17Partners Center for Personalized Medicine, Partners Health Care, Boston, MA, United States
3.
Inhibition of the Receptor for Advanced Glycation End Products Restores Cholesterol Efflux in THP-1 Human Macrophages Exposed to Plasma from Type 1 Diabetes Mellitus Patients
Jorge Mejia Corletto1, 3, Siham Accacha1, 3, Iryna Voloshyna2, 3, Nicolle Siegart2, 3, Lora Kasselman2, 3, Mariano Castro Magana1, Joshua DeLeon2, 3, Allison B. Reiss2, 3
1Pediatric Endocrinology, Winthrop University Hospital, Mineola, NY, United States 2Medicine, Winthrop University Hospital, Mineola, NY, United States 3Winthrop Research Institute, Winthrop University Hospital, Mineola, NY, United States
4.
Regenerative Asynchrony Is a Driver in Chronic Inflammation in Aging
Claire E. Hoptay, Sarah Alcala, Eric Hoffman, Robert J. Freishtat
Center of Genetic Medicine, Children's National Health System, Washington, DC, United States
5.
Quantitative Analysis of Desmopressin (DDAVP) Response in Adult Patients with Type 1 von Willebrand Disease
Achuta K. Guddati
Hematology/Oncology, SUNY Downstate Medical Center, Brooklyn, NY, United States
6.
Insulin and Glucose Affect Amyloid Precursor Protein Processing Genes in a Neuronal Cell Culture Model: Linking Diabetes and Alzheimer's Disease
Hirra A. Arain1, 2, Allison B. Reiss1, 2, Nicolle M. Siegart1, 2, Lora J. Kasselman1, 2, Alan M. Jacobson1, Mark M. Stecker1, 3
1Winthrop Research Institute, Winthrop University Hospital, Mineola, NY, United States 2Medicine, Winthrop University Hospital, Mineola, NY, United States 3Neuroscience, Winthrop University Hospital, Mineola, NY, United States
7.
Integrated Pathway Analysis of MicroRNA Expression in Plasma of Ovarian Cancer (OvCa) Patients Shows Lack of BH3 Protein Dependent Signaling
Iuliana Shapira1, Ali Naboush1, Ashtami Banavali1, Elvira Neculiseanu1, Kumar Guddati1, Michael Kopf1, Cathleen Mason2, Annette Lee2
1Medicine, SUNY Downstate Medical Center, Brooklyn, NY, United States 2The Feinstein Institute for Medical Research, Manhasset, NY, United States
8.
Impact of Late Use Magnesium Sulfate in Inner City Children Hospitalized for Asthma Exacerbation
Prateek Shukla, Elena Aragona, Justin Wang, Dinesh Pillai
Division of Pulmonary and Sleep Medicine, Children's National Medical Center, Washington, DC, United States
9.
An in Vivo Model of Human Airways for Investigating Fibrosis
S Ferrante1, T Hackett2, C Hoptay1, J Engelhardt3, J Ingram4, Y Zhang3, S Alcala1, F Shaheen2, E Matz1, D Pillai1, R Freishtat1
1Children's National Medical Center, Washington, DC, United States 2Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada 3University of Iowa, Iowa City, IA, United States 4Duke University, Durham, NC, United States
10.
Cholesterol Flux Pathway Abnormalities Induced by Plasma from Patients with Chronic Kidney Disease
Nobuyuki Miyawaki1, 3, Farah Daccueil1, 3, Nicolle M. Siegart2, 3, Joseph Mattana1, 3, Iryna Voloshyna2, Lora J. Kasselman2, 3, Joshua De Leon3, Allison B. Reiss2, 3
1Nephrology, Winthrop University Hospital, Mineola, NY, United States 2Winthrop Research Institute, Winthrop University Hospital, Mineola, NY, United States 3Medicine, Winthrop University Hospital, Mineola, NY, United States
11.
The Adenosine A2A Receptor Agonist UK-432,097 Stimulates Anti-Atherogenic Reverse Cholesterol Transport Proteins in THP-1 Human Macrophages
Samiraly Moosa1, 2, Iryna Voloshyna 1, Nicolle M. Siegart1, 2, Joshua De Leon2, Steven E. Carsons1, 2, Lora J. Kasselman1, 2, Michael J. Littlefield1, Allison B. Reiss1, 2
1Winthrop Research Institute, Winthrop University Hospital, Mineola, NY, United States 2Medicine, Winthrop University Hospital, Mineola, NY, United States
12.
The Overuse of Stress Ulcer Prophylaxis on Admission and Discharge at a Tertiary Care Teaching Hospital: An Observational Study
Joshua Jackson2, Jared M. Okun1, Naveen Paddu2
1New York Medical College, Valhalla, NY, United States 2Brookdale University Medical Center, Brooklyn, NY, United States
10:30 AM - 10:45 AM
BREAK
10:45 AM - 11:00 AM
RESEARCH!AMERICA ADVOCACY WORKSHOP
"Your Role in Shaping Science Policy through Advocacy"

Anna Briseno, Senior Communications Specialist, Research!America
11:00 AM - 11:45 AM
7TH ANNUAL FORMER AFMR/AFCR PRESIDENT'S ADDRESS
"Crossing the Great Divide in Biomedical Research without a Horse"

Robert J. Freishtat, MD, MPH, Children's National Medical Center, Washington DC

Overview: There is a persistent disconnection between basic scientific advances and improved health. This is the so-called "Great Divide" in biomedical research. To cross this requires specific tools that used to be funded by government or pharma (the traditional horses). These are too often no longer there. In this presentation, audience members will learn about stories of crossing this "Great Divide" and alternative modes of transportation from basic science to healthier lives.
11:45 PM - 1:05 PM
MODERATED POSTER LUNCH COMPETITION
Moderators: Allison Reiss, MD
Winthrop University Hospital, Mineola NY

Oana Sandu, MD
Albert Enstein College of Medicine, Bronx NY
MP1.
Correcting Atherogenic Effects of Lupus Plasma on Macrophages with Resveratrol and Mycophenolate
Nicolle M. Siegart1, 2, Iryna Voloshyna1, Joshua DeLeon2, Steven E. Carsons2, 1, Isaac Teboul1, 2, Lora J. Kasselman1, 2, Joseph Mattana2, Allison B. Reiss1, 2
1Winthrop Research Institute, Winthrop-University Hospital, Mineola, NY, United States 2Medicine, Winthrop-University Hospital, Mineola, NY, United States
MP2.
Pathophysiology and Metabolic Phenotype of Low Body Mass Index Diabetes
Akankasha Tiwari, Riddhi Das Gupta, Sylvia Kehlenbrink, Michelle Carey, V Padmanaban, Nihal Thomas, Meredith Hawkins
Endocrinology, Albert Einstein College of Medicine, Bronx, NY, United States
MP3.
Role of Histone Deactylase (HDAC) Inhibitors in Adult T-Cell Lymphoma/Leukemia (ATL)
Nikhil Mukhi, Gurinder Sidhu, Jason Gonsky, Iuliana Shapira
Hematology/Oncology, SUNY Downstate Medical Center, Glen Oaks, NY, United States
MP4.
Microcytosis in Pernicious Anemia without Iron Deficiency or Thalassemia Trait
Maushmi Savjani, Padma Draksharam, Swaty Arora, Albert S. Braverman
Hematology/Oncology, SUNY Downstate Medical Center, Brooklyn, NY, United States
MP5.
Stable Isotope Labeled by Amino Acid in Culture (SILAC) Strategy to Analyze Human Middle Ear Epithelial Cells (HMEEC) Secretome in Response to NTHi Lysates: Evidence of the Implication of Exosomes in Otitis Media
Stéphanie Val, Stephanie Jeong, Marian Poley, Anna Krueger, Gustavo Nino, Kristy Brown, Diego Preciado
Sheihk Zayed Institute, Children's National Medical Center, Washington, DC, United States
MP6.
Homocysteine Level in PFO Related Stroke Patients with Respect to Medical Therapy vs PFO Closure
Wenjun Deng, Thomas Wickham, David McMullin, Kathleen Feeney, Scott Silverman, Ignacio Inglessis, Igor Palacios, Eng H. Lo, Ferdinando S. Buonanno, MingMing Ning
Neurology, Massachusetts General Hospital, Boston, MA, United States
MP7.
Families with Both Non-Hodgkin's Lymphoma (NHL) and Myeloma (MM): Anticipation and Male Transmission
Peter H. Wiernik, Janice P. Dutcher
Cancer Research Foundation, Chappaqua, NY, United States
MP8.
Monoclonal Gammopathy Characterization Using Serum Protein Electrophoresis in a Major Urban Population
Derek B. Laskar, Khurram Shafique, Chuanyong Lu, Alejandro Zuretti
Pathology, SUNY Downstate Medical Center, Brooklyn, NY, United States
MP9.
Sino-Nasal 5 Questionnaire Predicts Poor Asthma Control in Children with Persistent Asthma
Gurpreet Phull, Dominique Prue, Claudia Martinez, Krista Scheffey, Dinesh Pillai
Children's National Health System, Washington, DC, United States
MP10.
Analytical Style Predicts Religious and Teleological Belief
Samantha M. Steiner, Jeffrey C. Zemla, Steven Sloman
Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI, United States
MP11.
Comorbid Depression or Anxiety is Associated with Aortic Vascular Inflammation and Coronary Heart Disease beyond Traditional Cardiovascular Risk Factors in Psoriasis
Tsion Aberra, Aditya Joshi, Joseph Lerman, Justin Rodante, Joanna Silverman, Tarek Aridi, Marcus Chen, Martin Playford, Nehal Mehta
National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States
MP12.
Cryoglobulinemia in a Patient with Chronic Lymphocytic Leukemia (CLL)- A Case Report and Review of Literature of Renal Involvement in CLL
Swaty Arora1, Daniel Levitan2, Narottam Regmi1, Gurinder Sidhu1, Raavi Gupta2, Anthony Nacastri2, Subodh J. Saggi1, Albert Braverman1
1Medicine, SUNY Downstate, Brooklyn, NY, United States 2Pathology, SUNY Downstate, Brooklyn, NY, United States
MP13.
Important Role of Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) in Predicting tPA-Related Hemorrhagic Transformation
Wenjun Deng, Thomas Wickham, Davide McMullin, Kathleen Feeney, Ferdinando S. Buonanno, Eng H. Lo, MingMing Ning
Neurology, Massachusetts General Hospital, Boston, MA, United States
MP14.
Utilization of the Invasive Cardiac Laboratory for Immediate Cardiac Catheterization: A Quality Improvement Project
Douglas Friedman, Adam Bierzynski, Neil Coplan
Lenox Hill Hospital, Jersey City, NJ, United States
MP15.
Pediatric Sleep Questionnaire Detects Sleep Disordered Breathing in Asthmatics with Poor Nighttime Control
Rosemary Megalaa, Gurpreet Phull, Dominic Prue, Krista Scheffey, Dinesh Pillai
Children's National Health System, Washington, DC, United States
MP16.
Screening for Infective Endocarditis among Patients in an Inner City Hospital
Rishi Sharma1, Esha Garg1, Darcy Conaway 2, Mukesh Garg2
1Kansas City University of Medicine and Biosciences, Kansas city, MO, United States 2Nebraska Heart Institute, Hastings, NE, United States
1:05 PM - 3:05 PM
AFMR PRESIDENTIAL PLENARY SESSION (SCIENTIFIC SESSION II)
Moderators: Amir Zeki, MD, MAS
AFMR President, UC Davis, Sacramento CA

Armand Krikorian, MD
FACE, AFMR President-Elect, UIC/Advocate Christ Medical Center, Oak Lawn, IL
13.
Low Body Mass Index Diabetes is characterized by Impaired Insulin Secretion
Akankasha Tiwari, Riddhi Das Gupta, Michelle Carey, Anneka Wickramanayake, Chaithanya M. Kocherlakota, Nihal Thomas, Meredith Hawkins
Endocrinology, Albert Einstein College of Medicine, Bronx, NY, United States
14.
Angiopoeitin/Tie-2 Axis as a Therapeutic Target in Myelodysplastic Syndromes
Lohith S. Bachegowda1, Kerry Morrone1, Ioannis Mantzaris1, Shannon Winski2, Amit Verma1
1Albert Einstein College Of Medicine (AECOM), Bronx, NY, United States 2Array Biopharmaceutical, Boulder, CO, United States
15.
PFO Closure Reduces Plasma Levels of Serotonin in a Long Term Followup of Stroke Patients
Wenjun Deng, Davide McMullin, Thomas Wickham, Kathleen Feeney, Ignacio Inglessis, Igor Palacios, Ferdinando S. Buonanno, Eng H. Lo, MingMing Ning
Neurology, Massachusetts General Hospital, Boston, MA, United States
16.
Postpartum Depression Screening in a Pediatric ED
Lenore Jarvis, Gia Badolato, Kristen Breslin, Monika Goyal
Emergency Medicine, Children's National Health System, Washington, DC, United States
17.
Obese Adipocyte-Derived Exosomal miRNAs Targeting TGF-? Signaling are Associated with Poor Asthma Control
S Epstein, S Ferrante, E Nadler, M Barberio, M Goldberg, L Maltz, M Hubal, R Freishtat
Children's National Medical Center, Washington, DC, United States
18.
Improvement in Psoriasis Skin Disease Severity is Associated with Reduction of Coronary Plaque Burden
Joseph B. Lerman, Aditya A. Joshi, Justin Rodante, Tsion Aberra, Mohammad Tarek Kabbany, Taufiq F. Salahuddin, Qimin Ng, Joanna Silverman, Marcus Y. Chen, Nehal N. Mehta
National Heart, Lung and Blood Institute (NHLBI), Washington, DC, United States
19.
Resveratrol Improves Insulin Resistance with Anti-Inflammatory and "Browning" Effects in Adipose Tissue of Overweight Humans
Rebekah Gospin1, Oana Sandu1, Karen Gambina1, Akankasha Tiwari1, Michael Bonkowski2, Meredith Hawkins1
1Endocrinology, Albert Einstein College of Medicine, Bronx, NY, United States 2Harvard Medical School, Boston, MA, United States
20.
Nasopharynx Microbiome Composition Varies over Time in Pediatric Asthma
Marcos Perez-Losada, Allison Goldstein, Lamia Alamri, Keith A. Crandall, Robert J. Freishtat
Children's Research Institute, Children's National Medical Center, Washington, DC, United States
21.
Determinants of Vascular Inflammation by 18-Fluorodeoxyglucose PET/MRI: Findings from the Psoriasis, Atherosclerosis and Cardiometabolic Disease Initiative
Mohammad T. Kabbany, Aditya A. Joshi, Mark Ahlman, Justin Rodante, Joseph B. Lerman, Tsion Aberra, Joanna Silverman, Asha Dahiya, David A. Bluemke, Martin P. Playford, Nehal N. Mehta
National Heart, Lung and Blood Institute, Bethesda, MD, United States
22.
Mitotic Asynchrony Induces a Pro-Inflammatory State in Airway Epithelium
Sarah Alcala1, A Benton1, A Watson1, E Reeves2, J Damsker2, Z Wang1, K Nagaraju1, M Rose1, E Hoffman2, R Freishtat1
1Children's National Medical Center, Washington, DC, United States 2ReveraGen Biopharma, Rockville, MD, United States
23.
Vascular Inflammation and Aortic Wall Characteristics Modulate Following Lifestyle Changes in Psoriasis Patients at 1 Year Follow Up
Aditya Joshi, Parag Shukla, Tsion M. Aberra, Joseph B. Lerman, Balaji Natarajan, Qimin Ng, Joanna Silverman, Justin Rodante, Nehal N. Mehta
National Heart, Lung and Blood Institute, Bethesda, MD, United States
24.
Cocaine-Related Acute Coronary Syndrome and Incidence of Heart Disease
Rishi Sharma1, Esha Garg1, Darcy Conaway2, Mukesh Garg3
1Kansas City University of Medicine and Biosciences, Kansas city, MO, United States 2University of Missouri Kansas City, Kansas City, MO, United States 3Nebraska Heart Institute, Hastings, MO, United States
3:05 PM - 3:20 PM
BREAK
3:20 PM - 4:35 PM
CAREER DEVELOPMENT WORKSHOP:
Building a Faculty Development Program from Scratch
Joseph P. Merlino, MD, MPA, FACPsych
Vice President for Faculty Affairs and Professional Development, Professor of Clinical Psychiatry
SUNY Downstate, Brooklyn NY
4:35 PM - 5:00 PM
AWARD PRESENTATIONS
  • Poster Competition
  • Eastern Region Scholars
5:00 PM
ADJOURN
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