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AFMR Foundation

AFMR 2013 Eastern Regional Meeting

Program and Abstracts | Posters


TUESDAY, APRIL 16, 2013
Private Dining Room, Robert's
5:00 PM - 6:00 PM
WELCOME RECEPTION

WEDNESDAY, APRIL 17, 2013
Diplomat Ballroom
7:00 AM
EASTERN MEETING REGISTRATION & CONTINENTAL BREAKFAST
7:30 AM - 8:30 AM
BREAKFAST WORKSHOP: Lung Injury, Repair, and Remodeling
Moderator: Yulton Zhao, MD, PhP
University of Pittsburgh, Pittsburgh, PA

Acute Lung Injury: Current Clinical and Pathophysiologic Considerations
Bryan McVerry, MD
University of Pittsburgh, Pittsburgh, PA

GSK3? Regulates IL-22 Receptor Stability in Lung Epithelial Cells
Nathaniel Weathington, MD, PhD
University of Pittsburgh, Pittsburgh, PA

LPA1 Ubiquitination and Deubiquitination in Lung Injury
Yutong Zhao, MD, PhD
University of Pittsburgh, Pittsburgh, PA

Mesenchymal Stem Cells in Lung Repair
University of Pittsburgh, Pittsburgh, PA

8:45 AM - 9:00 AM
AFMR INTRODUCTION AND WELCOME
MingMing Ning, MD
Chair, AFMR Eastern Region
9:00 AM - 10:50 AM
SCIENTIFIC SESSION I

Moderators: Keith K. Colburn
VA Medical Center

Allison B. Reiss
Winthrop University Hospital
1
Risk Factors for All-Cause Readmission After Heart Failure Admission in Patients with Preserved or Reduced Ejection Fraction
Jonathan S. Siegfried1, Ofer Sagiv1, Eric Berkowitz1, Yuri Takhalov1, Alaeldin Eltom1, Suhash Patel1, Ralph Benjamin1, Benyam Alemu1, Deepinder Osahan1, Jennifer Siller1, Jennifer Ullman1, Georgia Panagopoulos1, Frank Messineo1, Neil L. Coplan1
1. Department of Cardiovascular Medicine, Lenox Hill Hospital, New York, NY, United States.
2
Mitotic Dyssynchrony Induces TGF-β1 in Airway Epithelial Progenitor Cells
Sarah Alcala1, A. Benton1, A. M. Watson1, S. Kureshi1, E. Reeves1, J. Damsker1, Z. Wang1, J. Anderson1, A. Williams1, A. Lee1, K. Hayes1, K. Nagaraju1, M. Rose1, E. P. Hoffman1, R. J. Freishtat1
1. Center of Genetic Medicine, Children's National Medical Center, Washington, DC, United States.
3
Determinants of Post-Ischemic Reactive Hyperemia Tissue Oxygen Saturation in Normal Subjects
Atif Afzal1, Manasi Bapat1, Christopher Knutson1, Rae Obasare1, Andrew Persits1, Haroon Kamran1, Louis Salciccioli1, Jason Lazar1
1. cardiology, SUNY Downstate Medical Center, Brooklyn, NY, United States.
4
Proteomic Profiling of the CF Secretome
Jennifer R. Peters-Hall1, 2, Kristy J. Brown1, Mary C. Rose1, 2
1. Center for Genetic Medicine Research, Children's National, Washington, DC, United States. 2. Integrative Systems Biology, The George Washington University, Washington, DC, United States.
5
Percutaneous Coronary Intervention for Acute Myocardial Infarction in Patients with Rheumatoid Arthritis
Sahil Khera1, Dhaval Kolte1, Sahil Agrawal1, Marjan Mujib1, Wilbert S. Aronow1, Chandrasekar Palaniswamy1, Jay V. Doshi1, Nivas Balasubramaniyam1, John A. McClung1
1. Internal Medicine-Cardiology, New York Medical College, Valhalla, NY, United States.
6
Identifying Directional Secretomes of In Vitro Differentiated Primary Normal Bronchial Epithelium
Dinesh Pillai1, 2, Binu J. Sankoorikal2, Eric Johnson1, Jessica Zurko1, Angelo Seneviratne1, Kristy J. Brown1, Yetrib Hathout1, Mary C. Rose1
1. Center for Genetic Medicine, Children's National Medical Center, Washington, DC, United States. 2. Division of Pulmonary Medicine, Children's National Medical Center, Washington, DC, United States.
7
High Levels of Circulating MicroRNAs from miR17-92 Family Indicate Favorable Outcomes in Ovarian Cancer Patients (OvCa)
Janaki Parameswaran1, Iuliana Shapira1, Annette Lee1, Michaela Oswald1, Keith Sultan1, Thomas Bradley1, Daniel Budman1
1. Hofstra NSLIJ School of Medicine, Manhasset, NY, United States.
8
Alpha II Spectrin Breakdown Product as a Potential Biomarker for Neurological Injury in Infants with Congenital Heart Disease undergoing Cardiopulmonary Bypass and Deep Hypothermic Cardiac Arrest
Parag Jain1, Michael Spaeder1, Richard Jonas2, Pranava Sinha2, Richard Levy1
1. Critical Care, Children's National Medical Center, Washington, DC, United States. 2. Cardiovascular Surgery, Children's National Medical Center, Washington, DC, United States.
9
IL33, Atopy, and Cholesterol Transport: A Unique Association
Tania Mucci1, Michael Littlefield1, Allison Reiss1, Luz Fonacier1, Steven Carsons1, Iryna Voloshyna1
1. Winthrop University Hospital, Mineola, NY, United States.
10
Determinants of Late Acute Rejection in Pediatric & Adolescent Kidney Transplant Recipients
Loai A. Eid1, Shamir Tuchman1, Asha Moudgil1
1. Nephrology, Children's National Medical Center, Washington, DC, United States.
11
Predictors of In-Hospital Mortality in Hospitalized Patients with Thrombotic Thrombocytopenic Purpura
Nivas Balasubramaniyam1, Dhaval Kolte1, Chandrasekar Palaniswamy2, Kiran Yalamanchili3, Wilbert S. Aronow2, John A. McClung2, Sahil Khera1, Jay V. Doshi2, Sachin Sule1, Stephen J. Peterson1
1. Internal Medicine, New York Medical College, Valhalla, NY, United States. 2. Cardiology, New York Medical College, Valhalla, NY, United States. 3. Hematology/Oncology, New York Medical College, Valhalla, NY, United States.
10:50 AM - 11:05 AM
BREAK
11:05 AM - 11:20 AM
RESEARCH!AMERICA ADVOCACY WORKSHOP

Speaking Up for Research: Advocacy in Action
Suzanne Ffolkes
Vice President of Communications
Research!America
11:20 AM - 12:05 PM
4TH ANNUAL FORMER AFMR/AFCR PRESIDENT'S ADDRESS
Medical Research in the Time of Sequestration: What to do until things get better


Suzanne Oparil, MD, FACC, FAHA, FASH
AFMR President, 1981-1982
Professor of Medicine
Professor of Cell, Developmental and Integrative Biology
Director, Vascular Biology and Hypertension Program
Of the Division of Cardiovascular Disease
Department of Medicine
The University of Alabama at Birmingham

Suzanne Oparil, MD is Professor of Medicine, Professor Cell, Developmental and Integrative Biology, and Director of the Vascular Biology and Hypertension Program of the Division of Cardiovascular Disease at the University of Alabama at Birmingham. She is Past President of the American Heart Association, American Society of Hypertension, and American Federation for Medical Research/AFCR. She has received numerous honorary memberships, lectureships and distinguished awards for her contributions to academic medicine, particularly the prevention and treatment of cardiovascular disease. She is a member of numerous prestigious societies, including the Association of American Physicians and the Institute of Medicine (IOM) of the National Academy of Sciences and has held important advisory positions with the National Institutes of Health, including expert panel member, membership on task forces, advisory and peer review committees, and various national and international writing committees. She serves as Co-Chair for the Joint National Committee charged by NHLBI, "Guidelines for the Management of High Blood Pressure in Adults – JNC 2013." Dr. Oparil has made many seminal contributions to vascular biology and hypertension research and has published over 700 peer reviewed articles on topics in clinical cardiology, atherosclerosis, heart failure, cardiovascular pathologies related to aging, vascular biology and hypertension.

12:05 PM - 1:35 PM
MODERATED POSTER LUNCH COMPETITION

Chair: Sharma S. Prabhakar
Texas Tech University Health Science Center
Moderators: Ravikumar Balasubramanian
Massachusetts General Hospital

Tobias B. Kulik
University of Rochester Medical Center

Matthew P. Sharron
Children’s National Medical Center
MP1
The Relationship of the Carotid Artery Gray Scale Median to Anatomic and Functional Measures of Cardiovascular Risk
Josef A. Brejt1, Aryeh Ginsburg1, Haroon Kamran1, AnthonyMarco Corbo1, Louis Salciccioli1, Jason Lazar1
1. Medicine/Cardiology, SUNY Downstate Medical Center, Brooklyn, NY, United States.
MP2
Effects of Topical Capsaicin on Carotid-Radial Pulse Wave Velocity in Healthy Subjects
Atif Afzal1, Manasi Bapat1, Thomas Pettie1, David Chabbot1, Andrew Persits1, Christopher Knutson1, Louis Salciccioli1, Jason Lazar1
1. cardiology, SUNY Downstate Medical Center, Brooklyn, NY, United States.
MP3
Presence of Third Molars Predicts Increased Mandible Fractures
David Milzman1, Dave Weiner1, Ryan Murray1
1. Emergency Medicine, Georgetown U School of Medicine, Washington, DC, United States.
MP4
Subjective and Motor Responses to Acute Intravenous (IV) Alcohol: Comparison of Clamp and Oral-Mimic Infusion Paradigms
Vatsalya Vatsalya1, Veronica Y. Schmidt1, Vijay A. Ramchandani1
1. Section on Human Psychopharmacology, LCTS, NIAAA, Bethesda, MD, United States.
MP5
Appropriate RBC Transfusions in the Intensive Care Setting: A Quality Improvement Initiative
Sandhya Samavedam1, 2, Arvind Vasudevan1, 2, Jeremiah Eagen2, Maureen Kane2
1. Internal medicine, The Wright Center for Graduate Medical Education, Scranton, PA, United States. 2. Internal Medicine, Regional Hospital of Scranton, Scranton, PA, United States.
MP6
CHD7 Mutations in Isolated GnRH Deficiency: The Genetics and Biological Implications for the Developmental Biology of GnRH Neurons
Jin-Ho Choi1, Ravikumar Balasubramanian1, Eleni P. Asimacopoulosb2, Konstantina M. Stankovic2, Lacey Plummer1, Cassandra L. Buck1, Flavia A. Costa-Barbosa1, Richard Quinton3, Todd D. Nebesio4, Veronica Mericq5, Paulina M. Merino6, Brian F. Meyer7, Dorota Monies7, James F. Gusella8, Nada Al Tassan7, William F. Crowley 1
1. Harvard Reproductive Endocrine Sciences Center, Massachusetts General Hospital, Boston, MA, United States. 2. Otolaryngology, Massachusetts Eye & Ear Infirmary, Boston, MA, United States. 3. Genetic Medicine, Newcastle University, Newcastle-upon-Tyne
MP7
Increased Visits; Decreased Deaths in HIV+ ED Patients
David Milzman1, 2, Scott Osborne2, Hahn Soe-Lin1
1. Georgetown U, Washington, DC, United States. 2. ED, Washignton Hospital Centers, Washington, DC, United States.
MP8
Sumatriptan is Effective for Migraine Headaches in the Pediatric Emergency Department
Naomi T. Hughes1, Bhawana Arora1, Kathleen Brown1
1. Emergency Department, Children's National Medical Center, Washington, DC, United States.
MP9
>Practices and Experiences of Pediatric Emergency Medicine Fellows in Debriefing after Medical Resuscitations in the Emergency Department
Lauren E. Staple1, Leticia M. Ryan1, Karen O'Connell1, Paul Mullan1, Angela T. Wratney2
1. Division of Emergency Medicine, Children's National Medical Center, Washington, DC, United States. 2. Division of Critical Care Medicine, Children's National Medical Center, Washington, DC, United States.
MP10
Upper and Lower Airway Inflammation Modulate the Phenotypical Expression of OSA in Children
Shehlanoor Huseni1, Maria Gutierrez2, Carlos Rodriguez-Marinez3, Cesar Nino4, Geovanny Perez1, Gustavo Nino1
1. Childrens National Medical Center, Washington , DC, United States. 2. Pennsylvania State University College of Medicine , Hershey, PA, United States. 3. National University of Colombia, Bogota, Colombia. 4. Javeriana University , Bogota, Colombia.
MP11
Response to Bronchodilators in Patients with Cystic Fibrosis
Tina Catanzaro1, Anastassios Koumbourlis1, 2
1. Pulmonary and Sleep Medicine, Children's National Medical Center, Washington, DC, United States. 2. School of Medicine, George Washington University, Washington, DC, United States.
MP12
Atherogenic Properties of Rheumatoid Arthritis Plasma: Effect on Cholesterol Efflux Genes in 20 Subjects
Sony Modayil1, Allison B. Reiss1, Michael J. Littlefield1, Elise Belilos1, Kristina B. Belostocki1, Lois A. Bonetti1, Gary C. Rosenblum1, Steven E. Carsons1, Iryna Voloshyna1
1. Medicine, Winthrop University Hospital, Mineola, NY, United States.
1:35 PM - 3:35 PM
SCIENTIFIC SESSION II

Moderators: Leticia M. Ryan
Children’s National Medical Center

Peter H. Wiernik
St. Lukes-Roosevelt Medical Center
12
Estrogen and TGFβ-1 Increase Fibronectin mRNA and Protein Expression In Asthmatic Epithelium
Asha S. Payne1, Humaira Mubdeen1, Kanneboyina Nagaraju1, Robert J. Freishtat1
1. Children's National Medical Center, Washington, DC, United States.
13
A New Artificial Neural Networks Model of Cardiovascular Risk in Renal Disease Outlines Carotid Artery Markers
Oana Sandu1, Iulian Nastac2, Jaime Uribarri3
1. ICTR, Albert Einstein College of Medicine, Bronx, NY, United States. 2. UPB, University Politehnica Bucharest, Bucharest, Romania. 3. Medicine, Mount Sinai School of Medicine, New York, NY, United States.
14
Acute Myocardial Infarction and In-Hospital Mortality After Carbon Monoxide Poisoning: An Analysis of the Nationwide Inpatient Sample 2002-2010
Marjan Mujib1, Sahil Khera1, Dhaval Kolte1, Chandrasekar Palaniswamy2, Jalaj Garg1, Wilbert S. Aronow2
1. Internal Medicine, New York Medical College, Ossining, NY, United States. 2. Cardiology, New York Medical College, Valhalla, NY, United States.
15
Adipocyte Exosomal miRNAs May Mediate The Effects Of Obesity On Lung Disease
Sarah Ferrante1, Evan Nadler1, Zuyi Wang1, Monica Hubal1, Dinesh Pillai1, Sammie Sevilla1, Andrew Wiles1, Julia Anderson1, Robert J. Freishtat1
1. Children's National Medical Center, Washington, DC, United States.
16
Comparison of Peak Troponin (cTnI) Levels Based on Various Patient Characteristics
David Milzman1, 2, George Hughes-Strange1, Anthony Napoli1
1. Georgetown U, Washington, DC, United States. 2. Emerg Med, Washington Hospital Center, Washngton, DC, United States.
17
Trends in Percutaneous Coronary Intervention and Outcomes Among Patients ≥ 80 Years of Age with ST-Elevation Myocardial Infarction
Dhaval Kolte1, Sahil Khera1, Marjan Mujib1, Chandrasekar Palaniswamy1, Tarunjit Singh1, Wilbert S. Aronow1
1. Internal Medicine-Cardiology, New York Medical College, Valhalla, NY, United States.
18
Novel Poly-Lactic Acid Nanofiber-Filled Slurry for Improved Elastic Cartilage Engineering from Human Umbilical Cord Mesenchymal Stem Cells
Alexandra Halevi1, 2, Montserrat Caballero1, Miles C. Wright3, John A. van Aalst1
1. Department of Plastic and Reconstructive Surgery, University of North Carolina, Chapel Hill, NC, United States. 2. Mount Sinai School of Medicine, New York, NY, United States. 3. CEO and Founder, Xanofi, Inc, Raleigh, NC, United States.
19
Repression of MUC5AC Gene Expression in Human Lung Epithelial Cells by Classical and Dissociative Steroids
Lindsay M. Garvin1, Yajun Chen2, Jesse M. Damsker3, Mary C. Rose1, 2
1. George Washington University, Washington, DC, United States. 2. Genetic Medicine, Children's National Medical Center, Washington, DC, United States. 3. ReveraGen BioPharma, Rockville, MD, United States.
20
Novel Urinary Biomarkers of Acute Kidney Injury and Mortality 3-Years After Cardiac Surgery
Steven Coca1, Amit Garg2, Heather Thiessen-Philbrook2, Jay Koyner3, Michael Shlipak4, Chirag Parikh1
1. Yale University, New Haven, CT, United States. 2. Western University, London, ON, Canada. 3. University of Chicago , Chicago, IL, United States. 4. University of California-San Francisco, San Francisco, CA, United States.
21
BMP-2 Synergizes the Bone Healing Effect of FGF-2 on Calvarial Defects in Mice
Liping Xiao1, Sylvain Catros2, Daisuke Ueno3, Colin Homer-Bouthiette 1, Lyndon Charles1, Liisa Kuhn1, Marja Hurley1
1. University of Connecticut Health Center, Farmington, CT, United States. 2. University of Bordeaux Segalen, Bordeaux, France. 3. Tsurumi University, Yokohama, Japan.
22
Practice Patterns in the Management of Febrile Neonates with No Lumbar Puncture
Priti Bhansali1, Neha Shah1, William Pastor1, Bernhard Wiedermann1
1. Pediatrics, Children's National Medical Center, Washington, DC, United States.
23
Bone Mineral Density in Overweight Children with and without Forearm Fractures
Leticia M. Ryan1, Stephen Teach1, Laura Tosi1, Catherine Gordon2, Michael Levine3, James Chamberlain1
1. Division of Emergency Medicine, Children's National Medical Center, Washington, DC, United States. 2. Hasbro Children's Hospital, Providence, RI, United States. 3. The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
3:35 PM - 3:50 PM
BREAK
3:50 PM - 5:05 PM
CAREER DEVELOPMENT WORKSHOP
Faculty Development Presentation Skills for Physicians and Researchers: Making Your Next Presentation Go Better Than Your Last

Scott C. Litin, MD
Mayo Clinic, Rochester, MN
5:05 PM - 6:05 PM
AFMR PRESIDENTIAL PLENARY SESSION (SCIENTIFIC SESSION III)

Moderators: Robert J. Freishtat
Children’s National Medical Center

Abraham Thomas
Henry Ford Hospital
24
High-throughput Signal Processing of Polysomnography Identifies Airflow-Independent Respiratory Features of OSA in Adults
Geovanny F. Perez1, C. L. Nino2, C. Rodriguez-Martinez3, M. Gutierrez4, S. Huseni1, G. Nino1
1. Children's National Medical Center, Washington , DC, United States. 2. Javeriana University, Bogota, Colombia. 3. Universidad Nacional de Colombia, Bogota, Colombia. 4. Pennsylvania State University College of Medicine , Hershey, PA, United States.
25
Expression of Cardiolipin Biosynthesis and Remodeling Enzymes in Adult Heart Failure
Jonathan E. Grudis1, Kathryn C. Chatfield2, Genevieve C. Sparagna4, Jamie Hijmans3, Rebecca D. Sobus3, Shelley D. Miyamoto2, Brian L. Stauffer3, 4
1. University of Colorado School of Medicine, Aurora, CO, United States. 2. Department of Pediatric Cardiology, Children's Hosptial Colorado, Aurora, CO, United States. 3. Department of Medicine, University of Colorado Denver, Aurora, CO, United States.
26
Advanced Glycation End Products (AGEs) Cause Pro-atherogenic Changes in Cholesterol Transport: A Possible Mechanism for Cardiovascular Risk in Diabetes
Jose D. Gamez2, 1, Iryna Voloshyna1, Michael J. Littlefield1, Mariano Castro-Magana2, Allison B. Reiss1
1. Medicine, Winthrop University Hospital, Mineola, NY, United States. 2. Pediatric Endocrinology, Winthrop University Hospital, Mineola, NY, United States.
27
Aging Is Sufficient to Induce Progenitor Cell Mitotic Dyssynchrony
Claire E. Hoptay1, 2, Sarah Alcala1, 2, Humaira Mubeen1, Andrew A. Wiles1, Aaron Williams1, Julia Anderson1, Jamie Margolis1, Eric Hoffman1, 2, Robert J. Freishtat1, 2
1. Genetic Medicine, Children's National Medical Center, Washington DC, DC, United States. 2. George Washington University Institute of Biomedical Sciences, Washington, DC, United States.
28
The Basic Domain of HIV-Tat is Essential for Targeting Tat to Lipid Rafts (LR) and its Regulation of FGF-2 Signaling in Human Podocytes.
Xuefang Xie 1, Anamaris Colberg-Poley2, 3, Jharna Das 1, Jinliang Li1, Aiping Zhang2, 3, Pingato Tang 1, Marina Jerebtsova 1, 3 J. Silvio Gutkind 4, Patricio Ray1, 3
1. Center for Cancer and Immunology Research , Children's National Medical Center, Washingrton DC , DC, United States. 2. Center for Genetic Medicine Research , Children's National Medical Center, Washingrton DC , DC, United States. 3. Pediatrics , The
29
Proteomic Profiles in Long Term Follow-up of Patent Foramen Ovale Related Stroke Patients
MingMing Ning1, Mary Lopez1, David A. Sarracino1, Kathleen Feeney1, Molly Thayer1, Mikaela Elia1, Hailey Koop1, David McMullin1, Zareh Demirjian1, Ignacio Inglessis-Azuaje1, Scott Silverman1, G. William Dec1, Igor Palacios1, Eng H. Lo1, Ferdinando S. Buonanno1
1. Clinical Proteomics Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
6:05 PM - 6:20 PM
AWARD PRESENTATIONS
- Poster Competition
- Eastern Region Scholars
6:20 PM
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